Université de Fribourg

Differential Sorting of the Vesicular Glutamate Transporter 1 into a Defined Vesicular Pool Is Regulated by Light Signaling Involving the Clock Gene Period2

Yelamanchili, Sowmya V. ; Pendyala, Gurudutt ; Brunk, Irene ; Darna, Mahesh ; Albrecht, Urs ; Ahnert-Hilger, Gudrun

In: The Journal of Biological Chemistry, 2006, vol. 281, no. 23, p. 15671–15679

Synaptic strength depends on the amount of neurotransmitter stored in synaptic vesicles. The vesicular transmitter content has recently been shown to be directly dependent on the expression levels of vesicular neurotransmitter transporters indicating that the transport capacity of synaptic vesicles is a critical determinant for synaptic efficacy. Using synaptic vesicles prepared from whole brain...