Université de Fribourg

Nucleotide excision repair efficiency in quiescent human fibroblasts is modulated by circadian clock

Bee, Leonardo ; Marini, Selena ; Pontarin, Giovanna ; Ferraro, Paola ; Costa, Rodolfo ; Albrecht, Urs ; Celotti, Lucia

In: Nucleic Acids Research, 2015, vol. 43, no. 4, p. 2126-2137

The efficiency of Nucleotide Excision Repair (NER)process is crucial for maintaining genomic integrity because in many organisms, including humans, it represents the only system able to repair a wide range of DNA damage. The aim of the work was to investigate whether the efficiency of the repair of photoproducts induced by UV-light is affected by the circadian phase at which irradiation occurred....