Université de Fribourg

Medicine in the fourth dimension

R.Cederroth, Christopher ; Albrecht, Urs ; Bass, Joseph ; Brown, Steven A. ; Dyhrfjeld-Johnsen, Jonas ; Gachon, Frederic ; Green, Carla B. ; Hastings, Michael H. ; Helfrich-Förster, Charlotte ; B.Hogenesch, John ; Lévi, Francis ; Loudon, Andrew ; B.Lundkvist, Gabriella ; H.Meijer, Johanna ; Rosbash, Michael ; S.Takahashi, Joseph ; Young, Michael ; Canlon, Barbara

In: Cell Metabolism, 2019, vol. 30, no. 2, p. 238–250

The importance of circadian biology has rarely been considered in pre-clinical studies, and even more when translating to the bedside. Circadian biology is becoming a critical factor for improving drug efficacy and diminishing drug toxicity. Indeed, there is emerging evidence showing that some drugs are more effective at nighttime than daytime, whereas for others it is the opposite. This...

Université de Fribourg

Klf15 orchestrates circadian nitrogen homeostasis

Jeyaraj, Darwin ; Scheer, Frank A. J. L. ; Ripperger, Jürgen A. ; Haldar, Saptarsi M ; Lu, Yuan ; Prosdocimo, Domenick A. ; Eapen, Sam J. ; Eapen, Betty L. ; Cui, Yingjie ; Mahabeleshwar, Ganapathi H. ; Lee, Hyoung gon ; Smith, Mark A. ; Casadesus, Gemma ; Mintz, Eric M. ; Sun, Haipeng ; Wang, Yibin ; Ramsey, Kathryn M. ; Bass, Joseph ; Shea, Steven A. ; Albrecht, Urs ; Jain, Mukesh K.

In: Cell Metabolism, 2012, vol. 15, no. 3, p. 311–323

Diurnal variation in nitrogen homeostasis is observed across phylogeny. But whether these are endogenous rhythms, and if so, molecular mechanisms that link nitrogen homeostasis to the circadian clock remain unknown. Here, we provide evidence that a clock-dependent peripheral oscillator, Krüppel-like factor 15 transcriptionally coordinates rhythmic expression of multiple enzymes involved in...