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Università della Svizzera italiana

T follicular helper cells promote a beneficial gut ecosystem for host metabolic homeostasis by sensing microbiota-derived extracellular ATP

Perruzza, Lisa ; Gargari, Giorgio ; Proietti, Michele ; Fosso, Bruno ; D'Erchia, Anna Maria ; Faliti, Caterina Elisa ; Rezzonico-Jost, Tanja ; Scribano, Daniela ; Mauri, Laura ; Colombo, Diego ; Pellegrini, Giovanni ; Moregola, Annalisa ; Mooser, Catherine ; Pesole, Graziano ; Nicoletti, Mauro ; Norata, Giuseppe Danilo ; Geuking, Markus B. ; McCoy, Kathy D. ; Guglielmetti, Simone ; Grassi, Fabio

In: Cell reports, 2017, vol. 18, no. 11, p. 2566-2575

The ATP-gated ionotropic P2X7 receptor regulates T follicular helper (Tfh) cell abundance in the Peyer’s patches (PPs) of the small intestine; deletion of P2rx7, encoding for P2X7, in Tfh cells results in enhanced IgA secretion and binding to commensal bacteria. Here, we show that Tfh cell activity is important for generating a diverse bacterial community in the gut and that sensing of...

Consortium of Swiss Academic Libraries

Connexins, pannexins, innexins: novel roles of "hemi-channels”

Scemes, Eliana ; Spray, David ; Meda, Paolo

In: Pflügers Archiv - European Journal of Physiology, 2009, vol. 457, no. 6, p. 1207-1226

Consortium of Swiss Academic Libraries

Influence of the activation status and of ATP on phosphoribulokinase degradation

Kamber, Lea ; Feller, Urs

In: Journal of Experimental Botany, 1998, vol. 49, no. 319, p. 139-144