Université de Fribourg

Proteasomal degradation induced by DPP9-mediated processing competes with mitochondrial protein import

Finger, Yannik ; Habich, Markus ; Gerlich, Sarah ; Urbanczyk, Sophia ; Logt, Erik ; Koch, Julian ; Schu, Laura ; Lapacz, Kim Jasmin ; Ali, Muna ; Petrungaro, Carmelina ; Salscheider, Silja Lucia ; Pichlo, Christian ; Baumann, Ulrich ; Mielenz, Dirk ; Dengjel, Jörn ; Brachvogel, Bent ; Hofmann, Kay ; Riemer, Jan

In: The EMBO Journal, 2020, vol. 39, no. 19, p. e103889

Plasticity of the proteome is critical to adapt to varying conditions. Control of mitochondrial protein import contributes to this plasticity. Here, we identified a pathway that regulates mitochondrial protein import by regulated N-terminal processing. We demonstrate that dipeptidyl peptidases 8/9 (DPP8/9) mediate the N-terminal processing of adenylate kinase 2 (AK2) en route to mitochondria....

Consortium of Swiss Academic Libraries

The PROSITE Database, Its Status in 1995

Bairoch, Amos ; Bucher, Philipp ; Hofmann, Kay

In: Nucleic Acids Research, 1996, vol. 24, no. 1, p. 189-196

Consortium of Swiss Academic Libraries

The PROSITE database, its status in 1997

Bairoch, Amos ; Bucher, Philipp ; Hofmann, Kay

In: Nucleic Acids Research, 1997, vol. 25, no. 1, p. 217-221

Consortium of Swiss Academic Libraries

The PROSITE database, its status in 1999

Hofmann, Kay ; Bucher, Philipp ; Falquet, Laurent ; Bairoch, Amos

In: Nucleic Acids Research, 1999, vol. 27, no. 1, p. 215-219