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Inference of chromosomal inversion dynamics from Pool-Seq data in natural and laboratory populations of Drosophila melanogaster

Kapun, Martin ; van Schalkwyk, Hester ; McAllister, Bryant ; Flatt, Thomas ; Schlötterer, Christian

In: Molecular Ecology, 2014, vol. 23, no. 7, p. 1813–1827

Sequencing of pools of individuals (Pool‐Seq) represents a reliable and cost‐effective approach for estimating genome‐wide SNP and transposable element insertion frequencies. However, Pool‐Seq does not provide direct information on haplotypes so that, for example, obtaining inversion frequencies has not been possible until now. Here, we have developed a new set of diagnostic marker...