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Are integrins still practicable targets for anti-cancer therapy?

Alday-Parejo, Begoña ; Stupp, Roger ; Rüegg, Curzio

In: Cancers, 2019, vol. 11, no. 7, p. 978

Correlative clinical evidence and experimental observations indicate that integrin adhesion receptors, in particular those of the αV family, are relevant to cancer cell features, including proliferation, survival, migration, invasion, and metastasis. In addition, integrins promote events in the tumor microenvironment that are critical for tumor progression and metastasis, including tumor...

Erratum to: MGMT methylation analysis of glioblastoma on the Infinium methylation BeadChip identifies two distinct CpG regions associated with gene silencing and outcome, yielding a prediction model for comparisons across datasets, tumor grades, and CIMP-status

Bady, Pierre ; Sciuscio, Davide ; Diserens, Annie-Claire ; Bloch, Jocelyne ; van den Bent, Martin ; Marosi, Christine ; Dietrich, Pierre-Yves ; Weller, Michael ; Mariani, Luigi ; Heppner, Frank ; Macdonald, David ; Lacombe, Denis ; Stupp, Roger ; Delorenzi, Mauro ; Hegi, Monika

In: Acta Neuropathologica, 2013, vol. 126, no. 1, p. 159-159

MGMT methylation analysis of glioblastoma on the Infinium methylation BeadChip identifies two distinct CpG regions associated with gene silencing and outcome, yielding a prediction model for comparisons across datasets, tumor grades, and CIMP-status

Bady, Pierre ; Sciuscio, Davide ; Diserens, Annie-Claire ; Bloch, Jocelyne ; van den Bent, Martin ; Marosi, Christine ; Dietrich, Pierre-Yves ; Weller, Michael ; Mariani, Luigi ; Heppner, Frank ; Mcdonald, David ; Lacombe, Denis ; Stupp, Roger ; Delorenzi, Mauro ; Hegi, Monika

In: Acta Neuropathologica, 2012, vol. 124, no. 4, p. 547-560

ATCT-08THE IMPACT OF EXTENDED ADJUVANT TEMOZOLOMIDE IN NEWLY-DIAGNOSED GLIOBLASTOMA: A SECONDARY ANALYSIS OF EORTC AND NRG ONCOLOGY/RTOG

Blumenthal, Deborah T. ; Stupp, Roger ; Zhang, Peixin ; Kim, Michelle M. ; Gilbert, Mark R. ; Nabors, Louis B. ; Mason, Warren P. ; van den Bent, Martin J. ; Hegi, Monika ; Golfinopoulos, Vassilis ; Erridge, Sara ; Perry, James ; Fink, Karen L. ; Brown, Paul ; Corn, Ben W. ; Karlovits, Stephen ; Schultz, Christopher ; Weller, Michael ; Mehta, Minesh P. ; Gorlia, Thierry

In: Neuro-Oncology, 2015, vol. 17, p. v2-v2

Cilengitide treatment of newly diagnosed glioblastoma patients does not alter patterns of progression

Eisele, Günter ; Wick, Antje ; Eisele, Anna-Carina ; Clément, Paul ; Tonn, Jörg ; Tabatabai, Ghazaleh ; Ochsenbein, Adrian ; Schlegel, Uwe ; Neyns, Bart ; Krex, Dietmar ; Simon, Matthias ; Nikkhah, Guido ; Picard, Martin ; Stupp, Roger ; Wick, Wolfgang ; Weller, Michael

In: Journal of Neuro-Oncology, 2014, vol. 117, no. 1, p. 141-145

ATNT-10DOES VALPROIC ACID IMPROVE SURVIVAL IN GLIOBLASTOMA? A META-ANALYSIS OF RANDOMIZED TRIALS IN NEWLY DIAGNOSED GLIOBLASTOMA

Happold, Caroline ; Gorlia, Thierry ; Chinot, Olivier ; Gilbert, Mark ; Nabors, Burt ; Wick, Wolfgang ; Pugh, Stephanie L. ; Hegi, Monika ; Cloughesy, Timothy ; Roth, Patrick ; Reardon, David ; Perry, James R. ; Mehta, Minesh ; Stupp, Roger ; Weller, Michael

In: Neuro-Oncology, 2015, vol. 17, p. v12-v12

Presence of an oligodendroglioma-like component in newly diagnosed glioblastoma identifies a pathogenetically heterogeneous subgroup and lacks prognostic value: central pathology review of the EORTC_26981/NCIC_CE.3 trial

Hegi, Monika ; Janzer, Robert-Charles ; Lambiv, Wanyu ; Gorlia, Thierry ; Kouwenhoven, Mathilde ; Hartmann, Christian ; von Deimling, Andreas ; Martinet, Danielle ; Besuchet Schmutz, Nathalie ; Diserens, Annie-Claire ; Hamou, Marie-France ; Bady, Pierre ; Weller, Michael ; van den Bent, Martin ; Mason, Warren ; Mirimanoff, René-Olivier ; Stupp, Roger ; Mokhtari, Karima ; Wesseling, Pieter

In: Acta Neuropathologica, 2012, vol. 123, no. 6, p. 841-852

Withholding temozolomide in glioblastoma patients with unmethylated MGMT promoter - still a dilemma?

Hegi, Monika E.

In: Neuro-Oncology, 2015, vol. 17, no. 11, p. 1425-1427

Targeted therapies on the horizon for malignant glioma

Hofer, Silvia ; Stupp, Roger

In: Targeted Oncology, 2010, vol. 5, no. 3, p. 157-160

A phase I pharmacokinetic study of hypoxic abdominal stop-flow perfusion with gemcitabine in patients with advanced pancreatic cancer and refractory malignant ascites

Kuemmerle, Andrea ; Decosterd, Laurent ; Buclin, Thierry ; Liénard, Danielle ; Stupp, Roger ; Chassot, Pierre-Guy ; Mosimann, François ; Lejeune, Ferdy

In: Cancer Chemotherapy and Pharmacology, 2009, vol. 63, no. 2, p. 331-341