Interkantonale Hochschule für Heilpädagogik Zürich HfH

Persistent hippocampal neural firing and hippocampal-cortical coupling predict verbal working memory load

Boran, Ece ; Fedele, Tommaso ; Klaver, Peter ; Hilfiker, Peter ; Stieglitz, Lennart ; Grunwald, Thomas ; Sarnthein, Johannes

In: Science Advances, 2019, vol. 5, no. 3, p. 1-14

The maintenance of items in working memory relies on persistent neural activity in a widespread network of brain areas. To investigate the influence of load on working memory, we asked human subjects to maintain sets of letters in memory while we recorded single neurons and intracranial encephalography (EEG) in the medial temporal lobe and scalp EEG. Along the periods of a trial, hippocampal...