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Università della Svizzera italiana

Effect of lactose pseudopolymorphic transition on the aerosolization performance of drug/carrier mixtures

Della Bella, Andrea ; Müller, Michele ; Danani, Andrea ; Soldati, Luciano ; Bettini, Ruggero

In: Pharmaceutics, 2019, vol. 11, no. 11, p. 576

Physico-chemical properties of lactose are key factors in adhesive mixtures used as dry powder inhaler (DPI). Despite the abundant literature on this topic, the effect of the polymorphism and pseudo-polymorphism of lactose has been seldom investigated and discussed although often lactose used in DPI is subjected to unit operations, which may alter its solid-state properties. Here, we studied...

Università della Svizzera italiana

Consumer empowerment in the digital economy : availing sustainable purchasing decisions

Gazzola, Patrizia ; Colombo, Gianluca ; Pezzetti, Roberta ; Nicolescu, Luminita

In: Sustainability, 2017, vol. 9, no. 5, p. 693

The advent of the digital economy and, implicitly, of competition in the online marketplace has triggered new challenges in terms of consumer protection approaches. Online, consumer skills are expected to be improved and the level of consumer awareness and engagement increased. These are the baseline prerequisites of the sustainable purchasing decision and, thus, should be considered as pillars...

Università della Svizzera italiana

Long non-coding RNAs as molecular signatures for canine B-Cell lymphoma characterization

Cascione, Luciano ; Giudice, Luca ; Ferraresso, Serena ; Marconato, Laura ; Giannuzzi, Diana ; Napoli, Sara ; Bertoni, Francesco ; Giugno, Rosalba ; Aresu, Luca

In: Non-coding RNA, 2019, vol. 5, no. 3, p. 47

Diffuse large B-cell lymphoma (DLBCL), marginal zone lymphoma (MZL) and follicular lymphoma (FL) are the most common B-cell lymphomas (BCL) in dogs. Recent investigations have demonstrated overlaps of these histotypes with the human counterparts, including clinical presentation, biologic behavior, tumor genetics, and treatment response. The molecular mechanisms that underlie canine BCL are...

Università della Svizzera italiana

The prospect and challenges to the flow of liquid biopsy in Africa

Oluwaseyi Temilola, Dada ; Wium, Martha ; Coulidiati, Tangbadioa Herve ; Adeola, Henry Ademola ; Carbone, Giuseppina Maria ; Catapano, Carlo Vittorio Institute of Oncology Research (IOR), Faculty of Biomedical Sciences, Università della Svizzera italiana, Switzerland ; Zerbini, Luiz Fernando

In: Cells, 2019, vol. 8, no. 8, p. 862

Liquid biopsy technologies have the potential to transform cancer patient management as it others non- invasive diagnosis and real-time monitoring of disease progression and treatment responses. The use of liquid biopsy for non-invasive cancer diagnosis can have pivotal importance for the African continent where access to medical infrastructures is limited, as it eliminates the need for...

Università della Svizzera italiana

Between utopian image and heterotopic reality : thinking/imagining participatory planning (and also hospitality) starting from reality

Bevilacqua, Maria Giovanna

In: Proceedings, 2017, vol. 1, no. 9, p. 873

Utopia is a place that does not exist; utopia is a non-existent model society in a non-existent model space. Utopia is an image. According to the definition given by Michel Foucault, hétéropies, unlike utopias, are places that actually exist. Heterotopies are at the same time non-physical and real and physical spaces. In the modern Western world, characterised by multiculturalism and by an...

Università della Svizzera italiana

Bayesian dependence tests for continuous, binary and mixed continuous-binary variables

Benavoli, Alessio ; De Campos, Cassio P.

In: Entropy, 2016, vol. 18, no. 9, p. 326

Tests for dependence of continuous, discrete and mixed continuous-discrete variables are ubiquitous in science. The goal of this paper is to derive Bayesian alternatives to frequentist null hypothesis significance tests for dependence. In particular, we will present three Bayesian tests for dependence of binary, continuous and mixed variables. These tests are nonparametric and based on the...

Università della Svizzera italiana

Non-causal computation

Baumeler, Ämin ; Wolf, Stefan

In: Entropy, 2017, vol. 19, no. 7, p. 326-334

Computation models such as circuits describe sequences of computation steps that are carried out one after the other. In other words, algorithm design is traditionally subject to the restriction imposed by a fixed causal order. We address a novel computing paradigm beyond quantum computing, replacing this assumption by mere logical consistency: We study non-causal circuits, where a fixed time...

Università della Svizzera italiana

Perceptions of job insecurity in Switzerland : evidence using verbal and numerical descriptors

Baruffini, Moreno

In: International journal of environmental research and public health, 2019, vol. 16, no. 10, p. 1785

The purpose of this paper is to examine perceptions of job insecurity among employees, applying a panel model that allows us to account for the business cycle. In addition, the data will enable the comparison of two measures of job insecurity, one with a cardinal scale, and one with an ordinal scale. First of all, this paper carries out a descriptive analysis of job insecurity, taking into...

Università della Svizzera italiana

VaR and CVaR implied in option prices

Barone Adesi, Giovanni

In: Journal of risk and financial management, 2016, vol. 9, no. 1, p. 2

VaR (Value at Risk) and CVaR (Conditional Value at Risk) are implied by option prices. Their relationships to option prices are derived initially under the pricing measure. It does not require assumptions about the distribution of portfolio returns. The effects of changes of measure are modest at the short horizons typically used in applications. The computation of CVaR from option price is very...

Università della Svizzera italiana

FJProf : profiling fork/join applications on the Java virtual machine

Rosales, Eduardo ; Rosà, Andrea ; Binder, Walter

An efficient fork/join application should maximize parallelism while minimizing overheads, and maximize locality while minimizing contention. However, there is no unique optimal implementation that best resolves such tradeoffs and failing in balancing them may lead to fork/join applications suffering from several issues (e.g., suboptimal forking, load imbalance, excessive synchronization),...