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Università della Svizzera italiana

Coating and functionalization strategies for nanogels and nanoparticles for selective drug delivery

Pinelli, Filippo ; Giuseppe Perale ; Filippo Rossi

In: Gels, 2020, vol. 6, no. 1, p. 6

Drug delivery is a fascinating research field with several development opportunities. Great attention is now focused on colloidal systems, nanoparticles, and nanogels and on the possibility of modifying them in order to obtain precise targeted drug delivery systems. The aim of this review is to give an overview of the main available surface functionalization and coating strategies that can be...

Università della Svizzera italiana

Food perceptions and dietary changes for chronic condition management in rural Peru : insights for health promotion

Perez-Leon, Silvana ; Pesantes, M. Amalia ; Aya Pastrana, Nathaly ; Raman, Shivani ; Miranda, Jaime ; Suggs, L. Suzanne

In: Nutrients, 2018, vol. 10, no. 11, p. 1563

Peru is undergoing a nutrition transition and, at the country level, it faces a double burden of disease where several different conditions require dietary changes to maintain a healthy life and prevent complications. Through semistructured interviews in rural Peru with people affected by three infectious and noninfectious chronic conditions (type 2 diabetes, hypertension, and...

Università della Svizzera italiana

Discrimination of non-local correlations

Montina, Alberto ; Wolf, Stefan

In: Entropy, 2019, vol. 21, no. 2, p. 104

In view of the importance of quantum non-locality in cryptography, quantum computation, and communication complexity, it is crucial to decide whether a given correlation exhibits non-locality or not. As proved by Pitowski, this problem is NP- complete, and is thus computationally intractable unless NP is equal to P. In this paper, we first prove that the Euclidean distance of given...

Università della Svizzera italiana

A large scale, app-based behaviour change experiment persuading sustainable mobility patterns : methods, results and lessons learnt

Cellina, Francesca ; Bucher, Dominik ; Mangili, Francesca ; Veiga Simão, José ; Rudel, Roman ; Raubal, Martin

In: Sustainability, 2019, vol. 11, no. 9, p. 2674

The present urban transportation system, mostly tailored for cars, has long shown its limitations. In many urban areas, public transportation and soft mobility would be able to effectively satisfy many travel needs. However, they tend to be neglected, due to a deep-rooted car dependency. How can we encourage people to make sustainable mobility choices, reducing car use and the related CO 2...

Università della Svizzera italiana

Bovine lactoferrin-induced CCL1 expression involves distinct receptors in monocyte-derived dendritic cells and their monocyte precursors

Latorre, Daniela ; Pulvirenti, Nadia ; Covino, Daniela Angela ; Varano, Barbara ; Purificato, Cristina ; Rainaldi, Gabriella ; Gauzzi, Maria Cristina ; Fantuzzi, Laura ; Conti, Lucia ; Donninelli, Gloria ; Del Cornò, Manuela ; Sabbatucci, Michela ; Gessani, Sandra ; Puddu, Patrizia

In: Toxins, 2015, vol. 7, no. 12, p. 5472-5483

Lactoferrin (LF) exhibits a wide range of immunomodulatory activities including modulation of cytokine and chemokine secretion. In this study, we demonstrate that bovine LF (bLF) up-modulates, in a concentration- and time-dependent manner, CCL1 secretion in monocytes (Mo) at the early stage of differentiation toward dendritic cells (DCs), and in fully differentiated immature Mo-derived DCs...

Università della Svizzera italiana

Gaussian mean field regularizes by limiting learned information

Kunze, Julius ; Kirsch, Louis ; Ritter, Hippolyt ; Barber, David

In: Entropy, 2019, vol. 21, no. 8, p. 758

Variational inference with a factorized Gaussian posterior estimate is a widely-used approach for learning parameters and hidden variables. Empirically, a regularizing effect can be observed that is poorly understood. In this work, we show how mean field inference improves generalization by limiting mutual information between learned parameters and the data through noise. We quantify a...

Università della Svizzera italiana

Insights into the effect of the G245S single point mutation on the structure of p53 and the binding of the protein to DNA

Lepre, Marco Gaetano ; Omar, Sara Ibrahim ; Grasso, Gianvito ; Morbiducci, Umberto ; Deriu, Marco Agostino ; Tuszynski, Jack A.

In: Molecules, 2017, vol. 22, no. 8, p. 1358

The transcription factor p53 is a potent tumor suppressor dubbed as the “guardian of the genome” because of its ability to orchestrate protective biological outputs in response to a variety of oncogenic stresses. Mutation and thus inactivation of p53 can be found in 50% of human tumors. The majority are missense mutations located in the DNA binding region. Among them, G245S is known to be...

Università della Svizzera italiana

Conformational dynamics and stability of U-shaped and S-shaped amyloid β assemblies

Grasso, Gianvito ; Rebella, Martina ; Muscat, Stefano ; Morbiducci, Umberto ; Tuszynski, Jack ; Danani, Andrea ; Deriu, Marco A.

In: International journal of molecular sciences, 2018, vol. 19, no. 2, p. 571

Alzheimer’s disease is the most fatal neurodegenerative disorder characterized by the aggregation and deposition of Amyloid β (Aβ) oligomers in the brain of patients. Two principal variants of Aβ exist in humans: Aβ1–40 and Aβ1–42. The former is the most abundant in the plaques, while the latter is the most toxic species and forms fibrils more rapidly. Interestingly, fibrils of...

Università della Svizzera italiana

Protein environment : a crucial triggering factor in Josephin domain aggregation : the role of 2,2,2-trifluoroethanol

Visentin, Cristina ; Navarro, Susanna ; Grasso, Gianvito ; Regonesi, Maria Elena ; Deriu, Marco Agostino ; Tortora, Paolo ; Ventura, Salvador

In: International journal of molecular sciences, 2018, vol. 19, no. 8, p. 2151

The protein ataxin-3 contains a polyglutamine stretch that triggers amyloid aggregation when it is expanded beyond a critical threshold. This results in the onset of the spinocerebellar ataxia type 3. The protein consists of the globular N-terminal Josephin domain and a disordered C-terminal tail where the polyglutamine stretch is located. Expanded ataxin-3 aggregates via a two-stage...

Università della Svizzera italiana

Selective ß2-adrenoceptor agonists and relevant hyperlactatemia : systematic review and meta-analysis

Liedtke, Alina G. ; Lava, Sebastiano A. G. ; Milani, Gregorio P. ; Agostoni, Carlo ; Gilardi, Viola ; Bianchetti, Mario G. ; Treglia, Giorgio ; Faré, Pietro B.

In: Journal of clinical medicine, 2020, vol. 9, no. 1, p. 71

Selective ß2-agonists have been imputed as potential cause of l-hyperlactatemia since the 1970s. To document the prevalence of hyperlactatemia associated with selective ß2-agonists and to investigate the predisposing factors, we searched for published articles until April 2019 pertaining to the interplay of administration of selective ß2-agonists and circulating l-lactic acid in the Excerpta...