In: Computer aided geometric design, 2021, vol. 88, p. 11
Bézier curves are indispensable for geometric modelling and computer graphics. They have numerous favourable properties and provide the user with intuitive tools for editing the shape of a parametric polynomial curve. Even more control and flexibility can be achieved by associating a shape parameter with each control point and considering rational Bézier curves, which comes with the...
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Thèse de doctorat : Università della Svizzera italiana, 2002 ; 2002ECO001.
This thesis explores a way of representing the structure of the international trade system and of understanding its behaviour. Its main contribution is a model, developed following computer simulation methodology, that deals with interactions and interdependencies in international trade, and consequently, with the study of patterns of trade and trading bloc formation. The simulation model allows...
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Thèse de doctorat : Università della Svizzera italiana, 2005 ; 2005COM004.
A common opinion in the Requirements Traceability field is that solution design, i.e. the design of the application solutions, may be derived directly from requirements refinement; according to current industrial practices and to some specific experiences, this dissertation proposes a different thesis: the design process is not a fully rational and explicit sequence of actions; designers keep...
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In: The European Journal of Public Health, 2015, vol. 25, p. -
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Thèse de doctorat : Università della Svizzera italiana, 2017 ; 2017COM014.
The prevalence of overweight and obesity represents a serious health problem, and is a risk factor for several non- communicable diseases. Poor nutrition and lack of regular physical activity are among the primary determinants of overweight and obesity. Data show that overweight and obesity rates are high in, and that the Swiss population does not adhere to the nutritional guidelines provided...
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In: Communications Biology, 2019, vol. 2, p. 174
Dna2 is an essential nuclease-helicase that acts in several distinct DNA metabolic pathways including DNA replication and recombination. To balance these functions and prevent unscheduled DNA degradation, Dna2 activities must be regulated. Here we show that Saccharomyces cerevisiae Dna2 function is controlled by sumoylation. We map the sumoylation sites to the N-terminal regulatory domain of...
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In: Chromosoma, 2018, vol. 127, no. 2 (June), p. 187–214
DNA double-strand breaks arise accidentally upon exposure of DNA to radiation, chemicals or result from faulty DNA metabolic processes. DNA breaks can also be introduced in a programmed manner, such as during the maturation of the immune system, meiosis or cancer chemo- or radiotherapy. Cells have developed a variety of repair pathways, which are fine-tuned to the specific needs of a cell....
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In: Educational Technology Research and Development, 2013, vol. 61, no. 4, p. 581-605
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Thèse de doctorat : Università della Svizzera italiana, 2011.
The present dissertation has as a main goal to identify and describe relevant design and communication processes taking place during co-design meetings, in a way suitable to inform practice in similar settings in the field of eLearning design and development. The need for such a research emerges from the inadequacy of prescriptive models that can guide professionals in their communication...
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Thèse de doctorat : Università della Svizzera italiana, 2012 ; 2012COM006.
Since the 1990s, a wide debate has been generated around the "learners-new media dichotomy", with a consequent journalistic reverberation. In particular, expressions like “digital natives”, “Y” generation, or “net-generation” contributed to diffuse the hypothesis that– since the 1980s – a generation of learners with typical characteristics related to their great familiarity with...
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