In: Biosensors, 2018, vol. 8, no. 1, p. 1-15
Endocrine Disrupting Compounds (EDCs) are chemical substances shown to interfere with endogenous hormones affecting the endocrine, immune and nervous systems of mammals. EDCs are the causative agents of diseases including reproductive disorders and cancers. This highlights the urgency to develop fast and sensitive methods to detect EDCs, which are detrimental even at very low concentrations....
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In: mSphere, 2018, vol. 3, no. 1, p. e00518-17
Extensive antigenic diversity within the GII.4 genotype of human norovirus is a major driver of pandemic emergence and a significant obstacle to development of cross- protective immunity after natural infection and vaccination. However, human and mouse monoclonal antibody studies indicate that, although rare, antibodies to conserved GII.4 blockade epitopes are generated. The mechanisms by...
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Thèse de doctorat : Università della Svizzera italiana, 2018 ; 2018ECO015.
We investigate the shape of risk appetite when the bank is financed also with contingent convertible bonds (CoCos). Our contribution to the existent literature is to assess risk appetite in a multi-dimensional perspective and to account for differences among banks' clusters, especially in a world with CoCos and policy rates approaching zero or negative figures. In our model, the bank objective...
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In: EMBO molecular medicine, 2018, vol. 10, p. e8879
Human memory B cells and plasma cells represent a rich source of antibodies that have been selected in response to human pathogens. In the last decade, different methods have been developed to interrogate the human memory repertoire and isolate monoclonal antibodies. I will discuss how a target‐agnostic approach based on high‐throughput screening of antibodies produced by cultured B cells...
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In: F1000Research, 2018, vol. 7, p. 95
Chemokine signaling is essential for coordinated cell migration in health and disease to specifically govern cell positioning in space and time. Typically, chemokines signal through heptahelical, G protein-coupled receptors to orchestrate cell migration. Notably, chemokine receptors are highly dynamic structures and signaling efficiency largely depends on the discrete contact with the ligand....
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In: Frontiers in immunology, 2017, vol. 8, p. 1233
C-C chemokine receptor-like 2 (CCRL2) is a non-signaling seven-transmembrane domain (7-TMD) receptor related to the atypical chemokine receptor (ACKR) family. ACKRs bind chemokines but do not activate G protein-dependent signaling or cell functions. ACKRs were shown to regulate immune functions in vivo by their ability to scavenge chemokines from the local environment. This study was ...
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In: Scientific reports, 2017, vol. 7, p. 11657
The effects of epicutaneous allergen administration on systemic immune responses in allergic and non-allergic individuals has not been investigated with defined allergen molecules. We studied the effects of epicutaneous administration of rBet v 1 and rBet v 1 fragments on systemic immune responses in allergic and non-allergic subjects. We conducted a clinical trial in which rBet v 1 and two...
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In: Cell reports, 2017, vol. 20, no. 8, p. 1921-1935
DNA double-strand break (DSB) repair by homologous recombination (HR) is initiated by CtIP/MRN-mediated DNA end resection to maintain genome integrity. SAMHD1 is a dNTP triphosphohydrolase, which restricts HIV- 1 infection, and mutations are associated with Aicardi-Goutières syndrome and cancer. We show that SAMHD1 has a dNTPase-independent function in promoting DNA end resection to facilitate...
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In: Journal of computational and applied mathematics, 2019, vol. 349, p. 292-301
Barycentric rational Floater–Hormann interpolants compare favourably to classical polynomial interpolants in the case of equidistant nodes, because the Lebesgue constant associated with these interpolants grows logarithmically in this setting, in contrast to the exponential growth experienced by polynomials. In the Hermite setting, in which also the first derivatives of the interpolant are...
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In: Journal of computational and applied mathematics, 2019, vol. 350, p. 114-129
Barycentric coordinates provide a convenient way to represent a point inside a triangle as a convex combination of the triangle’s vertices and to linearly interpolate data given at these vertices. Due to their favourable properties, they are commonly applied in geometric modelling, finite element methods, computer graphics, and many other fields. In some of these applications, it is desirable...
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