In: Npj vaccines, 2017, vol. 2, p. 7
Bovine respiratory syncytial virus, a major cause of respiratory disease in calves, is closely related to human RSV, a leading cause of respiratory disease in infants. Recently, promising human RSV-vaccine candidates have been engineered that stabilize the metastable fusion (F) glycoprotein in its prefusion state; however, the absence of a relevant animal model for human RSV has complicated...
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In: The journal of biological chemistry, 2015, vol. 290, no. 39, p. 23631-23645
Although the accumulation of a misfolded and protease-resistant form of the prion protein (PrP) is a key event in Prion pathogenesis, the cellular factors involved in its folding and quality control are poorly understood. PrP is a glycosylated and disulfide-bonded protein synthesized at the endoplasmic reticulum (ER). The ER foldase ERp57 (also known as Grp58) is highly expressed in the brain...
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In: International journal of molecular sciences, 2018, vol. 19, no. 8, p. 2151
The protein ataxin-3 contains a polyglutamine stretch that triggers amyloid aggregation when it is expanded beyond a critical threshold. This results in the onset of the spinocerebellar ataxia type 3. The protein consists of the globular N-terminal Josephin domain and a disordered C-terminal tail where the polyglutamine stretch is located. Expanded ataxin-3 aggregates via a two-stage...
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In: Journal of experimental medicine, 2014, vol. 211, no. 7, p. 1273-1280
The preexisting HIV-1–specific T cell repertoire must influence both the immunodominance of T cells after infection and immunogenicity of vaccines. We directly compared two methods for measuring the preexisting CD4+ T cell repertoire in healthy HIV-1–negative volunteers, the HLA-peptide tetramer enrichment and T cell library technique, and show high concordance (r = 0.989). Using the...
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In: Swiss medical weekly, 2014, vol. 144, p. w14001
The endoplasmic reticulum (ER) is an intracellular compartment dedicated to the synthesis and maturation of secretory and membrane proteins, totalling about 30% of the total eukaryotic cells proteome. The capacity to produce correctly folded polypeptides and to transport them to their correct intra- or extracellular destinations relies on proteostasis networks that regulate and balance the...
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Thèse de doctorat : Università della Svizzera italiana, 2012 ; 2012INFO004.
Recent years have seen the rapid growth of social media platforms that enable people to express their thoughts and perceptions on the web and share them with other users. Many people write their opinion about products, movies, people or events on blogs, forums or review sites. The so-called User Generated Content is a good source of users’ opinion and mining it can be very useful for a...
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In: Theoretical Chemistry Accounts, 2005, vol. 114, no. 1-3, p. 145-152
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Partial replication is a way to increase the scalability of replicated systems since updates only need to be applied to a subset of the system’s sites, thus allowing replicas to handle independent parts of the workload in parallel. In this paper, we propose P-Store, a partial database replication protocol for wide area networks. In P-Store, each transaction T optimistically executes on one...
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In: Brain sciences, 2021, vol. 11, no. 6, p. 16
When COVID-19 was declared as a pandemic, many countries imposed severe lockdowns that changed families’ routines and negatively impacted on parents’ and children’s mental health. Several studies on families with children with autism spectrum disorder (ASD) revealed that lockdown increased the difficulties faced by individuals with ASD, as well as parental distress. No studies have...
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In: Journal of ethnicity in substance abuse, 2021, p. 1-19
Aims: To examine psychometric properties of the Daily Drinking Questionnaire (DDQ) in a Mediterranean “wet” drinking culture. Methods: Three studies were conducted using random samples drawn from a representative sample of Italian young adults (N¼5,955; females ¼ 62%; mean age ¼ 27): Study 1 explored the factorial structure of weekly alcohol consumption; in Study 2 multi-group...
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