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Università della Svizzera italiana

Multi-targeting bioactive compounds extracted from essential oils as kinase inhibitors

Maruca, Annalisa ; Lanzillotta, Delia ; Rocca, Roberta ; Lupia, Antonio ; Costa, Giosuè ; Catalano, Raffaella ; Moraca, Federica ; Gaudio, Eugenio ; Ortuso, Francesco ; Artese, Anna ; Trapasso, Francesco ; Alcaro, Stefano

In: Molecules, 2020, vol. 25, no. 9, p. 14 p

Essential oils (EOs) are popular in aromatherapy, a branch of alternative medicine that claims their curative effects. Moreover, several studies reported EOs as potential anti- cancer agents by inducing apoptosis in different cancer cell models. In this study, we have considered EOs as a potential resource of new kinase inhibitors with a polypharmacological profile. On the other hand,...

Public access from May 8, 2022
Università della Svizzera italiana

Secrecy in the age of transparency : an investigation into legitimations, conceptions and practices of non-disclosure

Heide, Marlen ; Villeneuve, Jean-Patrick (Dir.)

Thèse de doctorat : Università della Svizzera italiana, 2019 ; 2019COM004.

The objective of this research is to illustrate the complexity and fluidity of the relationship between secrecy and transparency by considering the multiple rationales that serve to justify secrecy. The conceptual contribution of this thesis lies at two levels: (1) the reconceptualization of national security secrecy from realism to risk management and (2) the implications of such...

Università della Svizzera italiana

Experiential learning under ambiguity

Wahle, Thorsten ; Martignoni, Dirk (Dir.)

Thèse de doctorat : Università della Svizzera italiana, 2020 ; 2020ECO003.

In this dissertation I study choice contexts of learning under ambiguity. Experiential learning takes place by making choices, observing the outcomes, and altering future choices accordingly. Over time, such learning is expected to improve choices and outcomes but only when decision makers can classify outcomes as either successes or failures. This dichotomous outcome has clear behavioral...

Università della Svizzera italiana

Labour market outcomes : Careers, transitions and durations

Malfitano, Paolo ; Maggi, Rico (Dir.)

Thèse de doctorat : Università della Svizzera italiana, 2020 ; 2020ECO004.

This thesis contributes to labour economics by considering a wide range of factors influencing career paths, transitions to self- employment and duration in entrepreneurship. In the past literature, several studies have analysed labour market outcomes, transitions and durations. Nevertheless, there is the need of knowing more about the influence of individual and background characteristics on...

Università della Svizzera italiana

Living heritage and sustainable tourism

Cantoni, Lorenzo ; De Ascaniis, Silvia ; Elgin-Nijhuis, Karin

Lugano : Università della Svizzera italiana, 2020

ISBN: 978-88-6101-020-8

Università della Svizzera italiana

The environmental cost and the accident externality of driving : evidence from the Swiss franc’s appreciation

Bello, Piera

This study investigates the effects of driving on air quality and road safety by exploiting exogenous variation in traffic flows associated with the Swiss franc’s appreciation. During the Swiss franc’s appreciation, the volume of cars crossing the Swiss-Italian border rose considerably– the higher purchasing power of Swiss francs in the Euro area induced more Italian workers to cross the...

Università della Svizzera italiana

How computational chemistry and drug delivery techniques can support the development of new anticancer drugs

Garofalo, Mariangela ; Grazioso, Giovanni ; Cavalli, Andrea ; Sgrignani, Jacopo

In: Molecules, 2020, vol. 25, no. 7, p. 22 p

The early and late development of new anticancer drugs, small molecules or peptides can be slowed down by some issues such as poor selectivity for the target or poor ADME properties. Computer-aided drug design (CADD) and target drug delivery (TDD) techniques, although apparently far from each other, are two research fields that can give a significant contribution to overcome these problems....

Università della Svizzera italiana

Systematic review of level 1 and level 2 screening tools for Autism Spectrum Disorders in toddlers

Petrocchi, Serena ; Levante, Annalisa ; Lecciso, Flavia

In: Brain sciences, 2020, vol. 10, no. 3, p. 31 p

The present study provides a systematic review of level 1 and level 2 screening tools for the early detection of autism under 24 months of age and an evaluation of the psychometric and measurement properties of their studies. Methods: Seven databases (e.g., Scopus, EBSCOhost Research Database) were screened and experts in the autism spectrum disorders (ASD) field were questioned; Preferred...

Università della Svizzera italiana

Asset prices and demand shocks

Barbon, Andrea ; Franzoni, Francesco (Dir.)

Thèse de doctorat : Università della Svizzera italiana, 2020 ; 2020ECO002.

My dissertation consists of three chapters, each of which focuses on a different area of research in asset pricing. The first chapter deals with the informational role of brokerage firms during fire sales in the equity market. The second chapter exploits the ETF program by the bank of Japan as a quasi-natural experiment to measure the slope of the equity demand curve. The last chapter presents...

Università della Svizzera italiana

Arl13b regulates breast cancer cell migration and invasion by controlling integrin-mediated signaling

Casalou, Cristina ; Faustino, Alexandra ; Silva, Fernanda ; Ferreira, Inês C. ; Vaqueirinho, Daniela ; Ferreira, Andreia ; Castanheira, Pedro ; Barona, Teresa ; Ramalho, José S. ; Serpa, Jacinta ; Félix, Ana ; Barral, Duarte C.

In: Cancers, 2019, vol. 11, no. 10, p. 1461

Breast cancer is the first cause of cancer-related mortality among women worldwide, according to the most recent estimates. This mortality is mainly caused by the tumors’ ability to form metastases. Cancer cell migration and invasion are essential for metastasis and rely on the interplay between actin cytoskeleton remodeling and cell adhesion. Therefore, understanding the mechanisms by which...