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Università della Svizzera italiana

Statistical solutions for regressions-type models with big spatial data

Ghiringhelli, Chiara ; Mira, Antonietta (Dir.) ; Arbia, Giuseppe (Codir.)

Thèse de doctorat : Università della Svizzera italiana, 2020 ; 2020ECO011.

These last decades have witnessed an explosion of data collection and diffusion in all fields of human society. In many scientific fields researchers are becoming aware of a big data problem and of the need to manage it properly, combining the tools offered by statistics, computer, data science and informatics. This is particularly true for geo-located data, which can be collected in a...

Università della Svizzera italiana

Multilevel minimization in trust-region framework : algorithmic and software developments

Kopaničáková, Alena ; Krause, Rolf (Dir.)

Thèse de doctorat : Università della Svizzera italiana, 2020 ; 2020INFO021.

The field of scientific computing is associated with the modeling of complex physical phenomena. The resulting numerical models are often described by differential equations, which, in many cases, can be related to non-convex minimization problems. Thus, after discretization, the solution of large-scale non-convex optimization problem is required. Various iterative solution strategies can be...

Università della Svizzera italiana

RESTalk : a visual and textual DSL for modelling RESTful conversations

Ivanchikj, Ana ; Pautasso, Cesare (Dir.)

Thèse de doctorat : Università della Svizzera italiana, 2021 ; 2021INFO001.

Digitalization is all around us, even more so in pandemic times where substantial part of our lives has been moved online. One of the key enablers of digitalization are the Application Programming Interfaces (APIs) which enable the communication and exchange of data between different systems. They abstract from the implementation details of the underlying systems and allow for the monetization...

Università della Svizzera italiana

Firms talk, suppliers walk : analyzing the locus of greenwashing in the blame game and introducing ‘vicarious greenwashing’

Pizzetti, Marta ; Gatti, Lucia ; Seele, Peter

In: Journal of business ethics, 2019, p. 51 p

Greenwashing is a phenomenon that is linked to scandals that often occur at the supply-chain level. Nevertheless, research on this subject remains in its infancy; much more is needed to advance our understanding of stakeholders’ reactions to greenwashing. We propose here a new typology of greenwashing, based on the locus of discrepancy, i.e. the point along the supply-chain where the...

Università della Svizzera italiana

Advanced metaheuristics for the probabilistic orienteering problem

Chou, Xiaochen ; Gambardella, Luca Maria (Dir.) ; Montemanni, Roberto (Codir.)

Thèse de doctorat : Università della Svizzera italiana, 2020 ; 2020INFO020.

Stochastic Optimization Problems take uncertainty into account. For this reason they are in general more realistic than deterministic ones, meanwhile, more difficult to solve. The challenge is both on modelling and computation aspects: exact methods usually work only for small instances, besides, there are several problems with no closed-form expression or hard- to-compute objective functions....

Università della Svizzera italiana

Structure and function analysis of an antibody recognizing all influenza A subtypes

Kallewaard, Nicole L. ; Corti, Davide ; Collins, Patrick J. ; Neu, Ursula ; McAuliffe, Josephine M. ; Benjamin, Ebony ; Wachter-Rosati, Leslie ; Palmer-Hill, Frances J. ; Yuan, Andy Q. ; Walker, Philip A. ; Vorlaender, Matthias K. ; Bianchi, Siro ; Guarino, Barbara ; De Marco, Anna ; Vanzetta, Fabrizia ; Agatic, Gloria ; Foglierini, Mathilde ; Pinna, Debora ; Fernandez-Rodriguez, Blanca ; Fruehwirth, Alexander ; Silacci, Chiara ; Ogrodowicz, Roksana W. ; Martin, Stephen R. ; Sallusto, Federica ; Suzich, JoAnn A. ; Lanzavecchia, Antonio ; Zhu, Qing ; Gamblin, Steven J. ; Skehel, John J.

In: Cell, 2016, vol. 166, no. 3, p. 596-608

Influenza virus remains a threat because of its ability to evade vaccine-induced immune responses due to antigenic drift. Here, we describe the isolation, evolution, and structure of a broad-spectrum human monoclonal antibody (mAb), MEDI8852, effectively reacting with all influenza A hemagglutinin (HA) subtypes. MEDI8852 uses the heavy-chain VH6-1 gene and has higher potency and breadth when...

Università della Svizzera italiana

The mediatization of the air : wireless telegraphy and the origins of a transnational space of communication, 1900-1910s

Rikitianskaia, Maria ; Balbi, Gabriele ; Lobinger, Katharina

In: Journal of communication, 2018, vol. 68, no. 4, p. 758–779

Airspace today is densely penetrated by Wi-Fi networks, GPS services, and broadcasting and mobile phone signals. This process, what we call the mediatization of the air, is not so new, as it began in the first two decades of the 20th century, with the advent of wireless telegraphy. Based on archival research, this paper shows that wireless telegraphy mediatized the air and made it a matter of...

Università della Svizzera italiana

The antibody response to Plasmodium falciparum : cues for vaccine design and the discovery of receptor-based antibodies

Tan, Joshua ; Piccoli, Luca ; Lanzavecchia, Antonio

In: Annual Review of Immunology

P. falciparum remains a serious public health problem and a continuous challenge for the immune system due to the complexity and diversity of the pathogen. Recent advances from several laboratories in the characterization of the antibody response to the parasite have led to the identification of critical targets for protection and revealed a new mechanism of diversification based on the...

Università della Svizzera italiana

Identification and structure of a multidonor class of head-directed influenza-neutralizing antibodies reveal the mechanism for its recurrent elicitation

Sao-Fong Cheung, Crystal ; Fruehwirth, Alexander ; Paparoditis, Philipp Carl Georg ; Shen, Chen-Hsiang ; Foglierini, Mathilde ; Joyce, M. Gordon ; Leung, Kwanyee ; Piccoli, Luca ; Rawi, Reda ; Silacci-Fregni, Chiara ; Tsybovsky, Yaroslav ; Verardi, Raffaello ; Wang, Lingshu ; Wang, Shuishu ; Yang, Eun Sung ; Zhang, Baoshan ; Zhang, Yi ; Chuang, Gwo-Yu ; Corti, Davide ; Mascola, John R. ; Shapiro, Lawrence ; Kwong, Peter D. ; Lanzavecchia, Antonio ; Zhou, Tongqing

In: Cell reports, 2020, vol. 32, no. 9, p. 12 p

Multidonor antibodies are of interest for vaccine design because they can in principle be elicited in the general population by a common set of immunogens. For influenza, multidonor antibodies have been observed against the hemagglutinin (HA) stem, but not the immunodominant HA head. Here, we identify and characterize a multidonor antibody class (LPAF-a class) targeting the HA head. This class...

Università della Svizzera italiana

Antibody-guided vaccine design : identification of protective epitopes

Lanzavecchia, Antonio ; Frühwirth, Alexander ; Perez, Laurent ; Corti, Davide

In: Current opinion in immunology, 2016, vol. 41, no. August, p. 62-67

In the last decade, progress in the analysis of the human immune response and in the isolation of human monoclonal antibodies have provided an innovative approach to the identification of protective antigens which are the basis for the design of vaccines capable of eliciting effective B-cell immunity. In this review we illustrate, with relevant examples, the power of this approach that can...