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Università della Svizzera italiana

Does health literacy reinforce disease knowledge gain? : a prospective observational study of hungarian COPD patients

Papp-Zipernovszky, Orsolya ; Csabai, Márta ; Schulz, Peter J. ; Varga, János T.

In: Journal of clinical medicine, 2021, vol. 10, no. 17, p. 13

We set out to measure the health literacy (HL) of COPD patients using the Short Test of Functional Health Literacy (S- TOFHLA), perception-based screening questions (BHLS), and a specific disease knowledge test (COPD-Q). Our main focus is the relationship between functional HL and patients’ disease-knowledge, which contributes to the clarification of the relationship between the different...

Università della Svizzera italiana

Autoimmmune hepatitis

Terziroli Beretta-Piccoli, Benedetta ; Mieli Vergani, Giorgina ; Vergani, Diego

In: Cellular & molecular immunology, 2021, p. 19

Autoimmune hepatitis (AIH) is a T-cell mediated, inflammatory liver disease affecting all ages and characterized by female preponderance, elevated serum transaminase and immunoglobulin G levels, positive circulating autoantibodies, and presence of interface hepatitis at liver histology. AIH type 1, affecting both adults and children, is defined by positive anti- nuclear and/or antismooth muscle...

Università della Svizzera italiana

Autoimmune hepatitis : serum autoantibodies in clinical practice

Terziroli Beretta-Piccoli, Benedetta ; Mieli Vergani, Giorgina ; Vergani, Diego

In: Clinical reviews in allergy & immunology, 2021, p. 14

Circulating autoantibodies are a key diagnostic tool in autoimmune hepatitis (AIH), being positive in 95% of the cases if tested according to dedicated guidelines issued by the International Autoimmune Hepatitis Group. They also allow the distinction between type 1 AIH, characterized by positive anti-nuclear and/or anti-smooth muscle antibody, and type 2 AIH, characterized by positive...

Università della Svizzera italiana

Posterior reversible leukoencephalopathy syndrome associated with acute postinfectious glomerulonephritis : systematic review

Orlando, Corinne ; Milani, Gregorio P. ; Simonetti, Giacomo D. ; Goeggel Simonetti, Barbara ; Lava, Sebastiano A. G. ; Wyttenbach, Rolf ; Bianchetti, Mario G. ; Cristallo Lacalamita, Marirosa

In: Pediatric nephrology, 2021, p. 9

Background Kidney diseases are a recognized cause of posterior reversible leukoencephalopathy syndrome, usually abbreviated as PRES. The purpose of this review was to systematically address the association between acute postinfectious glomerulonephritis and PRES. Methods We performed a systematic review of the literature on acute postinfectious glomerulonephritis associated with PRES. The...

Università della Svizzera italiana

A new constructive heuristic driven by machine learning for the traveling salesman problem

Mele, Umberto Junior ; Gambardella, Luca Maria ; Montemanni, Roberto

In: Algorithms, 2021, vol. 14, no. 9, p. 25

Recent systems applying Machine Learning (ML) to solve the Traveling Salesman Problem (TSP) exhibit issues when they try to scale up to real case scenarios with several hundred vertices. The use of Candidate Lists (CLs) has been brought up to cope with the issues. A CL is defined as a subset of all the edges linked to a given vertex such that it contains mainly edges that are believed to be...

Università della Svizzera italiana

Recommendations on screen time, sleep and physical activity : associations with academic achievement in Swiss adolescents

Marciano, Laura ; Camerini, Anne-Linda

In: Public health, 2021, vol. 198, p. 211-217

Objectives: This study aimed to investigate how meeting international recommendations for screen time (<2 h/day), moderate-to-vigorous physical activity (MVPA; at least 60 min/day) and sleep (8e10 h/night), as well as media multitasking (MMI) as a form of screen time, impact academic achievement in early adolescence. Study design: A prospective design was used, where self-report measures...

Università della Svizzera italiana

Network theory and switching behaviors : a user guide for analyzing electronic records databases

Gronchi, Giorgio ; Raglianti, Marco ; Giovannelli, Fabio

In: Future internet, 2021, vol. 13, no. 9, p. 12

As part of studies that employ health electronic records databases, this paper advocates the employment of graph theory for investigating drug-switching behaviors. Unlike the shared approach in this field (comparing groups that have switched with control groups), network theory can provide information about actual switching behavior patterns. After a brief and simple introduction to...

Università della Svizzera italiana

Large scale simulation of pressure induced phase-field fracture propagation using Utopia

Zulian, Patrick ; Kopaničáková, Alena ; Nestola, Maria Giuseppina Chiara ; Fink, Andreas ; Fadel, Nur Aiman ; VandeVondele, Joost ; Krause, Rolf

In: CCF transactions on high performance computing, 2021, no. 3, p. 407–426

Non-linear phase field models are increasingly used for the simulation of fracture propagation problems. The numerical simulation of fracture networks of realistic size requires the efficient parallel solution of large coupled non-linear systems. Although in principle efficient iterative multi-level methods for these types of problems are available, they are not widely used in practice due to...

Università della Svizzera italiana

Le malattie autoimmuni di fegato nell’adulto = Maladies auto-immunes du foie chez l’adulte

Terziroli Beretta-Piccoli, Benedetta ; De Gottardi, Andrea ; Vergani, Diego ; Mieli-Vergani, Giorgina

In: Schweizer gastroenterologie, 2021, vol. 2, no. 2, p. 56-66

L’epatite autoimmune è una infiammazione cronica del fegato che colpisce tutte le età, caratterizzata da transaminasi e immunoglo- buline G elevate, presenza di autoanticorpi, epatite dell’interfaccia alla biopsia epatica, e ottima risposta alla terapia con steroidi. Se non trattata, ha una sopravvivenza a 5 anni del 50 %. La colangite biliare primitiva è una patologia cronica...

Università della Svizzera italiana

Non-alcoholic fatty liver disease : metabolic, genetic, epigenetic and environmental risk factors

Juanola, Oriol ; Martínez-López, Sebastián ; Francés, Rubén ; Gómez-Hurtado, Isabel

In: International journal of environmental research and public health, 2021, vol. 18, no. 10, p. 24

Non-alcoholic fatty liver disease (NAFLD) is one of the most frequent causes of chronic liver disease in the Western world, probably due to the growing prevalence of obesity, metabolic diseases, and exposure to some environmental agents. In certain patients, simple hepatic steatosis can progress to non-alcoholic steatohepatitis (NASH), which can sometimes lead to liver cirrhosis and its...