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Università della Svizzera italiana

Human-robot interaction with pointing gestures : intuitive interaction between co-located humans and robots

Gromov, Boris ; Gambardella, Luca Maria (Dir.) ; Giusti, Alessandro (Codir.)

Thèse de doctorat : Università della Svizzera italiana, 2020 ; 2020INFO004.

Human-robot interaction (HRI) is an active area of research and an essential component for the effective integration of mobile robots in everyday environments. In this PhD work, we studied, designed, implemented, and experimentally validated new efficient interaction modalities between humans and robots that share the same workspace. The core of the work revolves around deictic (pointing)...

Università della Svizzera italiana

Parallel space-time multilevel methods with application to electrophysiology : theory and implementation

Benedusi, Pietro ; Krause, Rolf (Dir.)

Thèse de doctorat : Università della Svizzera italiana, 2020 ; 2020INFO005.

The goal of this thesis is to design and study an efficient strategy to solve possibly non-linear parabolic partial differential equations on massively parallel machines. Traditionally, when solving time-dependent problems, time stepping methods are used to advance the solution in time. These techniques are inherently sequential and therefore they introduce a bottleneck in the overall...

Università della Svizzera italiana

Maintenance fluid therapy with saline, dextrose-supplemented saline or lactated Ringer in childhood: short-term metabolic effects

Ricciuti, Alessandra ; Milani, Gregorio P. ; Tarantino, Silvia ; Ghilardi, Roberta ; Lava, Sebastiano A.G. ; Alberzoni, Marco ; Bianchetti, Mario G. ; Agostoni, Carlo

In: Nutrients, 2020, vol. 12, no. 5, p. 8 p

Maintenance with isotonic fluids is recommended in children with gastroenteritis and failure of oral rehydration therapy. However, little is known on the short-term effects of the commonly prescribed intravenous solutions on metabolic balance in children. The aim of this study is to report on our experience with normal saline, dextrose-supplemented saline and lactated Ringer solution. Methods:...

Università della Svizzera italiana

Multi-targeting bioactive compounds extracted from essential oils as kinase inhibitors

Maruca, Annalisa ; Lanzillotta, Delia ; Rocca, Roberta ; Lupia, Antonio ; Costa, Giosuè ; Catalano, Raffaella ; Moraca, Federica ; Gaudio, Eugenio ; Ortuso, Francesco ; Artese, Anna ; Trapasso, Francesco ; Alcaro, Stefano

In: Molecules, 2020, vol. 25, no. 9, p. 14 p

Essential oils (EOs) are popular in aromatherapy, a branch of alternative medicine that claims their curative effects. Moreover, several studies reported EOs as potential anti- cancer agents by inducing apoptosis in different cancer cell models. In this study, we have considered EOs as a potential resource of new kinase inhibitors with a polypharmacological profile. On the other hand,...

Università della Svizzera italiana

How computational chemistry and drug delivery techniques can support the development of new anticancer drugs

Garofalo, Mariangela ; Grazioso, Giovanni ; Cavalli, Andrea ; Sgrignani, Jacopo

In: Molecules, 2020, vol. 25, no. 7, p. 22 p

The early and late development of new anticancer drugs, small molecules or peptides can be slowed down by some issues such as poor selectivity for the target or poor ADME properties. Computer-aided drug design (CADD) and target drug delivery (TDD) techniques, although apparently far from each other, are two research fields that can give a significant contribution to overcome these problems....

Università della Svizzera italiana

Arl13b regulates breast cancer cell migration and invasion by controlling integrin-mediated signaling

Casalou, Cristina ; Faustino, Alexandra ; Silva, Fernanda ; Ferreira, Inês C. ; Vaqueirinho, Daniela ; Ferreira, Andreia ; Castanheira, Pedro ; Barona, Teresa ; Ramalho, José S. ; Serpa, Jacinta ; Félix, Ana ; Barral, Duarte C.

In: Cancers, 2019, vol. 11, no. 10, p. 1461

Breast cancer is the first cause of cancer-related mortality among women worldwide, according to the most recent estimates. This mortality is mainly caused by the tumors’ ability to form metastases. Cancer cell migration and invasion are essential for metastasis and rely on the interplay between actin cytoskeleton remodeling and cell adhesion. Therefore, understanding the mechanisms by which...

Università della Svizzera italiana

The novel TORC1/2 kinase inhibitor PQR620 has anti-tumor activity in lymphomas as a single agent and in combination with venetoclax

Tarantelli, Chiara ; Gaudio, Eugenio ; Hillmann, Petra ; Spriano, Filippo ; Sartori, Giulio ; Aresu, Luca ; Cascione, Luciano ; Rageot, Denise ; Kwee, Ivo ; Beaufils, Florent ; Zucca, Emanuele ; Stathis, Anastasios ; Wymann, Matthias P. ; Cmiljanovic, Vladimir ; Fabbro, Doriano ; Bertoni, Francesco

In: Cancers, 2019, vol. 11, no. 6, p. 775

The phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling cascade is an important therapeutic target for lymphomas. Rapamycin-derivates as allosteric mTOR complex 1 (TORC1) inhibitors have shown moderate preclinical and clinical anti-lymphoma activity. Here, we assessed the anti-tumor activity of PQR620, a novel brain penetrant dual TORC1/2 inhibitor, in 56...

Università della Svizzera italiana

Sedentary behaviour in Swiss children and adolescents : disentangling associations with the perceived and objectively measured environment

Bringolf-Isler, Bettina ; De Hoogh, Kees ; Schindler, Christian ; Kayser, Bengt ; Suggs, L. Suzanne ; Dössegger, Alain ; Probst-Hensch, Nicole ; The SOPHYA Study Group

In: International journal of environmental research and public health, 2018, vol. 15, no. 5, p. 918

Identifying correlates of sedentary behaviour across all levels of the ecological model and understanding their interrelations is a promising method to plan effective interventions. The present study examined whether the objectively assessed and the perceived neighbourhood are associated with children’s sedentary behaviour time (SBT). A comprehensive set of factors at different levels of...

Università della Svizzera italiana

The measurements and an elaborated understanding of Chinese eHealth literacy (C-eHEALS) in chronic patients in China

Chang, Angela ; Schulz, Peter J.

In: International journal of environmental research and public health, 2018, vol. 15, no. 7, p. 1553

The rapid rise of Internet-based technologies to disseminate health information and services has been shown to enhance online health information acquisition. A Chinese version of the electronic health literacy scale (C-eHEALS) was developed to measure patients’ combined knowledge and perceived skills at finding and applying electronic health information to health problems. A valid sample...

Università della Svizzera italiana

Mechanical and control design of an industrial exoskeleton for advanced human empowering in heavy parts manipulation tasks

Mauri, Alessandro ; Lettori, Jacopo ; Fusi, Giovanni ; Fausti, Davide ; Mor, Maurizio ; Braghin, Francesco ; Legnani, Giovanni ; Roveda, Loris

In: Robotics, 2019, vol. 8, no. 3, p. 65

Exoskeleton robots are a rising technology in industrial contexts to assist humans in onerous applications. Mechanical and control design solutions are intensively investigated to achieve a high performance human-robot collaboration (e.g., transparency, ergonomics, safety, etc.). However, the most of the investigated solutions involve high-cost hardware, complex design solutions and standard...