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Université de Fribourg

Identification of genes differentially expressed upon cocaine treatment and of new rat semaphorins

Brenz Verca-Kouznetsova, Maria ; Dreyer, Jean-Luc (Dir.)

Thèse de doctorat : Université de Fribourg : 2000 ; no 1329.

At the behavioral level drug addiction is defined as compulsion to take a drug with loss of control over apparently voluntary acts of drug seeking and drug taking. At the neuronal level drugs elicit two types of responses: neuronal adaptations, i.e. homeostatic responses to excessive stimulation, and synaptic plasticity. At the molecular level both processes are paralleled by changes in gene...

Université de Fribourg

Nuclear receptors as vehicles for gene transfer

Ceppi, Maurizio ; Rusconi, Sandro (Dir.)

Thèse de doctorat : Université de Fribourg : 2000 ; Nr. 1328.

Human gene therapy can be defined as the directed transfer of exogenous genes or other nucleotide sequences into somatic cells, for the purpose of preventing, correcting or healing various diseases. This novel approach to the therapy of human disorders is based on the realization that many previous medical treatments have usually been directed at the consequences of causative defects or at...

Université de Fribourg

Modelling markets dynamics : minority games and beyond

Challet, Damien ; Zhang, Yi-Cheng (Dir.) ; Dacorogna, Michel (Codir.)

Thèse de doctorat : Université de Fribourg : 2000 ; no 1303.

Starting from the El Farol's bar problem, we introduce the minority game, an extremely simple model of competition between adaptive agents. We study its properties, and find that it displays a phase transition with symmetry breaking. An adequate mathematical formalism is introduced and reveals the spin glass nature of the model. We prove that available information is a Lyapunov function for this...