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Université de Fribourg

Improving the assessment of communication competencies in a national licensing OSCE: lessons learned from an experts’ symposium

Monti, Matteo ; Klöckner-Cronauer, * , Christina ; Hautz, Stephanie C. ; Schnabel, Kai P. ; Breckwoldt, Jan ; Junod-Perron, Noëlle ; Feller, Sabine ; Bonvin, Raphael ; Huwendiek, Sören

In: BMC Medical Education, 2020, vol. 20, no. 1, p. 171

Background: As the communication competencies of physicians are crucial for providing optimal patient care, their assessment in the context of the high-stakes Objective Structured Clinical Examination (OSCE) is of paramount importance. Despite abundant literature on the topic, evidence-based recommendations for the assessment of communication competencies in high stakes OSCEs are scarce. As ...

Université de Fribourg

Impossibility results on stability of phylogenetic consensus methods

Delucchi, Emanuele ; Hoessly, Linard ; Paolini, Giovanni

In: Systematic Biology, 2020, vol. 69, no. 3, p. 557–565

We answer two questions raised by Bryant, Francis, and Steel in their work on consensus methods in phylogenetics. Consensus methods apply to every practical instance where it is desired to aggregate a set of given phylogenetic trees (say, gene evolution trees) into a resulting, “consensus” tree (say, a species tree). Various stability criteria have been explored in this context, seeking...

Université de Fribourg

Seismic monitoring in the Gugla rock glacier (Switzerland): ambient noise correlation, microseismicity and modelling

Guillemot, Antoine ; Helmstetter, Agnès ; Larose, Éric ; Baillet, Laurent ; Garambois, Stéphane ; Mayoraz, Raphaël ; Delaloye, Reynald

In: Geophysical Journal International, 2020, vol. 221, no. 3, p. 1719–1735

A network of seismometers has been installed on the Gugla rock glacier since October 2015 to estimate seismic velocity changes and detect microseismicity. These two processes are related to mechanical and structural variations occurring within the rock glacier. Seismic monitoring thus allows a better understanding of the dynamics of rock glaciers throughout the year. We observed seasonal...

Université de Fribourg

Arginase‐II promotes melanoma migration and adhesion through enhancing hydrogen peroxide production and STAT3 signaling

Yu, Yi ; Ladeiras, Diogo ; Xiong, Yuyan ; Boligan, Kayluz Frias ; Liang, Xiujie ; Gunten, Stephan ; Hunger, Robert E. ; Ming, Xiu‐Fen ; Yang, Zhihong

In: Journal of Cellular Physiology, 2020, p. jcp.29814

Elevated arginase type II (Arg‐II) associates with higher grade tumors. Its function and underlying molecular mechanisms in melanoma remain elusive. In the present study, we observed a significantly higher frequency of Arg‐II expression in melanoma of patients with metastasis than those without metastasis. Silencing Arg‐II in two human melanoma cell lines slowed down the cell growth,...

Université de Fribourg

Role of akt activation in PARP inhibitor resistance in cancer

Gallyas, Ferenc ; Sumegi, Balazs ; Szabo, Csaba

In: Cancers, 2020, vol. 12, no. 3, p. 532

Poly(ADP-ribose) polymerase (PARP) inhibitors have recently been introduced in the therapy of several types of cancers not responding to conventional treatments. However, de novo and acquired PARP inhibitor resistance is a significant limiting factor in the clinical therapy, and the underlying mechanisms are not fully understood. Activity of the cytoprotective phosphatidylinositol-3 kinase...

Université de Fribourg

Nanostructure generation during milk digestion in presence of a cell culture model simulating the small intestine

Hempt, Claudia ; Gontsarik, Mark ; Buerki-Thurnherr, Tina ; Hirsch, Cordula ; Salentinig, Stefan

In: Journal of Colloid and Interface Science, 2020, vol. 574, p. 430–440

Hypothesis: The development of advanced oral delivery systems for bioactive compounds requires the fundamental understanding of the digestion process within the gastrointestinal tract. Towards this goal, dynamic invitro digestion models, capable of characterising the molecular as well as colloidal aspects of food, together with their biological interactions with relevant invitro cell culture...

Université de Fribourg

DNA origami as emerging technology for the engineering of fluorescent and plasmonic-based biosensors

Loretan, Morgane ; Domljanovic, Ivana ; Lakatos, Mathias ; Rüegg, Curzio ; Acuna, Guillermo P.

In: Materials, 2020, vol. 13, no. 9, p. 2185

DNA nanotechnology is a powerful and promising tool for the development of nanoscale devices for numerous and diverse applications. One of the greatest potential fields of application for DNA nanotechnology is in biomedicine, in particular biosensing. Thanks to the control over their size, shape, and fabrication, DNA origami represents a unique opportunity to assemble dynamic and complex...

Université de Fribourg

Strong, machinable, and insulating chitosan–urea aerogels: toward ambient pressure drying of biopolymer aerogel monoliths

Guerrero-Alburquerque, Natalia ; Zhao, Shanyu ; Adilien, Nour ; Koebel, Matthias M. ; Lattuada, Marco ; Malfait, Wim J.

In: ACS Applied Materials & Interfaces, 2020, vol. 12, no. 19, p. 22037–22049

Biopolymer aerogels are an emerging class of materials with potential applications in drug delivery, thermal insulation, separation, and filtration. Chitosan is of particular interest as a sustainable, biocompatible, and abundant raw material. Here, we present urea-modified chitosan aerogels with a high surface area and excellent thermal and mechanical properties. The irreversible gelation of...

Université de Fribourg

One-step ring opening metathesis block-like copolymers and their compositional analysis by a novel retardation technique

Yasir, Mohammad ; Liu, Peng ; Markwart, Jens C. ; Suraeva, Oksana ; Wurm, Frederik R. ; Smart, Jansie ; Lattuada, Marco ; Kilbinger, Andreas F. M.

In: Angewandte Chemie International Edition, 2020, p. -

Using a one-step synthetic route for block copolymers avoids the repeated addition of monomers to the polymerization mixture, which can easily lead to contamination and, therefore, to the unwanted termination of chain growth. For this purpose, monomers (M1–M5) with different steric hindrances and different propagation rates are explored. Copolymerization of M1 (propagating rapidly) with M2...

Université de Fribourg

A nano-rattle SnO2@carbon composite anode material for high-energy Li-ion batteries by melt diffusion impregnation

Maharajan, Sivarajakumar ; Kwon, Nam Hee ; Brodard, Pierre ; Fromm, Katharina M.

In: Nanomaterials, 2020, vol. 10, no. 4, p. 804

The huge volume expansion in Sn-based alloy anode materials (up to 360%) leads to a dramatic mechanical stress and breaking of particles, resulting in the loss of conductivity and thereby capacity fading. To overcome this issue, SnO2@C nano- rattle composites based on < 10 nm SnO2 nanoparticles in and on porous amorphous carbon spheres were synthesized using a silica template and tin melting...