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Université de Fribourg

Mental imagery and colour cues can prevent interference between motor tasks

Lauber, Benedikt ; Kurz, Alexander ; Gollhofer, Albert ; Taube, Wolfgang

In: Neuropsychologia, 2019, vol. 124, p. 202–207

Motor interference can be observed when two motor tasks are learnt in subsequent order. The aim of the current study was to test two approaches potentially mitigating interference effects. The first approach used contextual colour cues requiring only little cognitive attention thus being assumed to be primarily implicit while the second, mental practice/rehearsal that demands much more active...

Université de Fribourg

Does the bilingual advantage in cognitive control exist and if so, what are its modulating factors? A systematic review

Noort, Maurits van den ; Struys, Esli ; Bosch, Peggy ; Jaswetz, Lars ; Perriard, Benoît ; Yeo, Sujung ; Barisch, Pia ; Vermeire, Katrien ; Lee, Sook-Hyun ; Lim, Sabina

In: Behavioral Sciences, 2019, vol. 9, no. 3, p. 27

Recently, doubts were raised about the existence of the bilingual advantage in cognitive control. The aim of the present review was to investigate the bilingual advantage and its modulating factors. We searched the Medline, ScienceDirect, Scopus, and ERIC databases for all original data and reviewed studies on bilingualism and cognitive control, with a cut-off date of 31 October 2018, thereby...

Université de Fribourg

Embodied semantics in a second language: critical review and clinical implications

Monaco, Elisa ; Jost, Lea B. ; Gygax, Pascal M. ; Annoni, Jean-Marie

In: Frontiers in Human Neuroscience, 2019, vol. 13, p. -

The role of the sensorimotor system in second language (L2) semantic processing as well as its clinical implications for bilingual patients has hitherto been neglected. We offer an overview of the issues at stake in this under-investigated field, presenting the theoretical and clinical relevance of studying L2 embodiment and reviewing the few studies on this topic. We highlight that (a) the...

Université de Fribourg

PARP inhibition induces Akt-mediated cytoprotective effects through the formation of a mitochondria-targeted phospho-ATM-NEMO-Akt-mTOR signalosome

Tapodi, Antal ; Bognar, Zita ; Szabo, Csaba ; Gallyas, Ferenc ; Sumegi, Balázs ; Hocsak, Enikő

In: Biochemical Pharmacology, 2019, vol. 162, p. 98–108

The cytoprotective effect of poly(ADP-ribose) polymerase 1 (PARP1) inhibition is well documented in various cell types subjected to oxidative stress. Previously, we have demonstrated that PARP1 inhibition activates Akt, and showed that this response plays a critical role in the maintenance of mitochondrial integrity and in cell survival. However, it has not yet been defined how nuclear PARP1...

Université de Fribourg

CX 3 CR1-CX 3 CL1-dependent cell-to-cell Japanese encephalitis virus transmission by human microglial cells

Lannes, Nils ; Garcia-Nicolàs, Obdullio ; Démoulins, Thomas ; Summerfield, Artur ; Filgueira, Luis

In: Scientific Reports, 2019, vol. 9, no. 1, p. 4833

The neurotropic Japanese encephalitis virus (JEV) is responsible for Japanese encephalitis, an uncontrolled inflammatory disease of the central nervous system. Microglia cells are the unique innate immune cell type populating the brain that cross- communicate with neurons via the CX3CR1-CX3CL1 axis. However, microglia may serve as a viral reservoir for JEV. Human microglia are able to transmit...

Université de Fribourg

Microneurography as a tool to develop decoding algorithms for peripheral neuro-controlled hand prostheses

Petrini, Francesco M. ; Mazzoni, Alberto ; Rigosa, Jacopo ; Giambattistelli, Federica ; Granata, Giuseppe ; Barra, Beatrice ; Pampaloni, Alessandra ; Guglielmelli, Eugenio ; Zollo, Loredana ; Capogrosso, Marco ; Micera, Silvestro ; Raspopovic, Stanisa

In: BioMedical Engineering OnLine, 2019, vol. 18, no. 1, p. 44

The usability of dexterous hand prostheses is still hampered by the lack of natural and effective control strategies. A decoding strategy based on the processing of descending efferent neural signals recorded using peripheral neural interfaces could be a solution to such limitation. Unfortunately, this choice is still restrained by the reduced knowledge of the dynamics of human efferent...

Université de Fribourg

TF-ChIP Method for Tissue-Specific Gene Targets

Perna, Amalia ; Alberi, Lavinia

In: Frontiers in Cellular Neuroscience, 2019, vol. 13, p. -

Chromatin immunoprecipitation (ChIP) is an assay developed in order to define the dynamic nature of transcription processes. This method has been widely employed to identify methylated and acetylated DNA sequences in a variety of organs both in animals and humans. Nevertheless, this technique is significantly less employed to study transcriptional targets of specific nuclear signaling factors...

Université de Fribourg

Extending the mathematical palette for developmental pattern formation: piebaldism

Dougoud, Michaël ; Mazza, Christian ; Schwaller, Beat ; Pecze, László

In: Bulletin of Mathematical Biology, 2019, vol. 81, no. 5, p. 1461–1478

Here, we present a theoretical investigation with potential insights on developmental mechanisms. Three biological factors, consisting of two diffusing factors and a cell- autonomous immobile transcription factor are combined with different feedback mechanisms. This results in four different situations or fur patterns. Two of them reproduce classical Turing patterns: (1) regularly spaced...

Université de Fribourg

Expected depth of random walks on groups

Bou-Rabee, Khalid ; Manolescu, Ioan ; Myropolska, Aglaia

In: Pacific Journal of Mathematics, 2019, vol. 298, no. 2, p. 267–284

Université de Fribourg

Regularity of quasi-n-harmonic mappings into NPC spaces

Guo, Chang-Yu ; Xiang, Chang-Lin

In: Annali di Matematica Pura ed Applicata (1923 -), 2019, vol. 198, no. 2, p. 367–380

We prove local Hölder continuity of quasi-n-harmonic mappings from Euclidean domains into metric spaces with non-positive curvature in the sense of Alexandrov. We also obtain global Hölder continuity of such mappings from bounded Lipschitz domains.