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Université de Fribourg

Eradication of a multidrug-resistant, carbapenemase-producing Klebsiella pneumoniae isolate following oral and intra-rectal therapy with a custom made, lytic bacteriophage preparation

Corbellino, Mario ; Kieffer, Nicolas ; Kutateladze, Mzia ; Balarjishvili, Nana ; Leshkasheli, Lika ; Askilashvili, Lia ; Tsertsvadze, George ; Rimoldi, Sara Giordana ; Nizharadze, Deia ; Hoyle, Naomi ; Nadareishvili, Lia ; Antinori, Spinello ; Pagani, Cristina ; Scorza, Daniele Giuseppe ; Romanò, Ai Ling Loredana ; Ardizzone, Sandro ; Danelli, Piergiorgio ; Gismondo, Maria Rita ; Galli, Massimo ; Nordmann, Patrice ; Poirel, Laurent

In: Clinical Infectious Diseases, 2020, vol. 70, no. 9, p. 1998–2001

In July 2017, a patient presented colonization with a multidrug-resistant, carbapenemase (KPC-3)-producing Klebsiella pneumoniae isolate. A custom-made, lytic bacteriophage preparation was administered to the patient in December 2017, with subsequent eradication of the microorganism and without adverse effects.

Université de Fribourg

Acute alcohol intoxication and expectations reshape the spatiotemporal functional architecture of executive control

Ribordy Lambert, Farfalla ; Wicht, Corentin A. ; Mouthon, Michael ; Spierer, Lucas

In: NeuroImage, 2020, vol. 215, p. 116811

While the deleterious effects of acute ethyl alcohol intoxication on executive control are well-established, the underlying spatiotemporal brain mechanisms remain largely unresolved. In addition, since the effects of alcohol are noticeable to participants, isolating the effects of the substance from those related to expectations represents a major challenge. We addressed these issues using a...

Université de Fribourg

Effects of continuous theta burst stimulation over the left DLPFC on mother tongue and second language production in late bilinguals: a behavioral and ERP study

Jost, Lea B. ; Pestalozzi, Maria I. ; Cazzoli, Dario ; Mouthon, Michael ; Müri, René M. ; Annoni, Jean‑Marie

In: Brain Topography, 2020, vol. 33, no. 4, p. 504–518

Clinical, neuroimaging, and non-invasive brain stimulation studies have associated the dorsolateral prefrontal cortex (DLPFC) with the multilingual language control system. Here, we investigated if this role is increased during the processing of the non- dominant language due to the higher cognitive/attentional demands. We used an inhibitory repetitive transcranial magnetic stimulation (rTMS)...

Université de Fribourg

Coronavirus infections in children including covid-19: an overview of the epidemiology, clinical features, diagnosis, treatment and prevention options in children

Petra, Zimmermann ; Nigel, Curtis

In: The Pediatric Infectious Disease Journal, 2020, vol. 39, no. 5, p. 355–368

Coronaviruses (CoVs) are a large family of enveloped, single-stranded, zoonotic RNA viruses. Four CoVs commonly circulate among humans: HCoV2-229E, -HKU1, -NL63 and -OC43. However, CoVs can rapidly mutate and recombine leading to novel CoVs that can spread from animals to humans. The novel CoVs severe acute respiratory syndrome coronavirus (SARS-CoV) emerged in 2002 and Middle East...

Université de Fribourg

Granzyme B attenuates bacterial virulence by targeting secreted factors

López León, Diego ; Matthey, Patricia ; Fellay, Isabelle ; Blanchard, Marianne ; Martinvalet, Denis ; Mantel, Pierre-Yves ; Filgueira, Luis ; Walch, Michael

In: iScience, 2020, vol. 23, no. 3, p. 100932

Pathogenic bacteria secrete virulence factors that interact with the human host to establish infections. The human immune system evolved multiple mechanisms to fight bacterial invaders, including immune proteases that were demonstrated to contribute crucially to antibacterial defense. Here we show that granzyme B degrades multiple secreted virulence mediators from Listeria monocytogenes,...

Université de Fribourg

Palynological study of carbonated mounds during the holocene along the atlantic and mediterranean moroccan margins

Rachid, Jihad ; Hssaida, Touria ; Hamoumi, Naima ; Terhzaz, Loubna ; Spezzaferri, Silvia ; Frank, Norbert ; Daghor, Lamia

In: Review of Palaeobotany and Palynology, 2020, vol. 278, p. 104213

A palynological study of carbonate mounds of Atlantic and Mediterranean Moroccan margins was conducted on sediment boxcores MD13-3441, MD13-3456, MD13-3461, MD13-3465, MD13-3468 collected during the oceanographic cruise MD 194/Eurofleet - GATEWAY, which took place on June 2013.The organic remaining revealed a dominance of dinoflagellate cysts over the continental fraction, which showed very...

Université de Fribourg

Emerging climate signals in the Lena River catchment: a non-parametric statistical approach

Pohl, Eric ; Grenier, Christophe ; Vrac, Mathieu ; Kageyama, Masa

In: Hydrology and Earth System Sciences, 2020, vol. 24, no. 5, p. 2817–2839

Climate change has far-reaching implications in permafrost-underlain landscapes with respect to hydrology, ecosystems, and the population's traditional livelihoods. In the Lena River catchment, eastern Siberia, changing climatic conditions and the associated impacts are already observed or expected. However, as climate change progresses the question remains as to how far we are along this...

Université de Fribourg

Synoptic conditions and atmospheric moisture pathways associated with virga and precipitation over coastal Adélie Land in Antarctica

Jullien, Nicolas ; Vignon, Étienne ; Sprenger, Michael ; Aemisegger, Franziska ; Berne, Alexis

In: The Cryosphere, 2020, vol. 14, no. 5, p. 1685–1702

Precipitation falling over the coastal regions of Antarctica often experiences low-level sublimation within the dry katabatic layer. The amount of water that reaches the ground surface is thereby considerably reduced. This paper investigates the synoptic conditions and the atmospheric transport pathways of moisture that lead to either virga – when precipitation is completely sublimated –...

Université de Fribourg

A taxonomic revision of geoemydid turtles from Siwalik-age of India and Pakistan

Garbin, Rafaella C. ; Bandyopadhyay, Saswati ; Joyce, Walter G.

In: European Journal of Taxonomy, 2020, no. 652, p. -

Neogene (Siwalik-aged) deposits from India and Pakistan have yielded many vertebrate fossils, of which most were named during the 19th century, including numerous geoemydid turtles. In contrast to many other faunal components from the Siwaliks, geoemydids have not undergone taxonomic revision for more than a century and most fossils have therefore been believed to correspond to recent taxa....

Université de Fribourg

An alternative interpretation of Peltochelys duchastelii as a paracryptodire

Joyce, Walter G. ; Rollot, Yann

In: Fossil Record, 2020, vol. 23, no. 1, p. 83–93

Peltochelys duchastelii is an enigmatic turtle from Early Cretaceous (middle Barremian–early Aptian) Sainte-Barbe Formation of Bernissart, Belgium. In more recent literature, there has been strong support for the trionychian affinities of this taxon, but this interpretation is less consistent with external data, in particular biogeography and temporal considerations. We provide a...