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Université de Fribourg

Controlling the strength of ferromagnetic order in YBa2Cu3O7/La2/3Ca1/3MnO3 multilayers

Andrés Prada, Roberto de ; Gaina, Roxana ; Biškup, N. ; Varela, M. ; Stahn, J. ; Bernhard, Christian

In: Physical Review B, 2019, vol. 100, no. 11, p. 115129

With dc magnetization and polarized neutron reflectometry we studied the ferromagnetic response of YBa2Cu3O7/La2/3Ca1/3MnO3 (YBCO/LCMO) multilayers that are grown with pulsed laser deposition. We found that whereas for certain growth conditions (denoted as A type) the ferromagnetic moment of the LCMO layer is strongly dependent on the structural details of the YBCO layer on which it is ...

Muséum d'histoire naturelle

Oiseaux

Paris, Paul

Paris : P. Lechevalier, 1921

(Faune de France ; 2)

Université de Fribourg

Mood effects after deep brain stimulation for Parkinson’s disease: an update

Accolla, Ettore A. ; Pollo, Claudio

In: Frontiers in Neurology, 2019, vol. 10, p. 617

Depression in Parkinson's Disease (PD) is a prevalent and invalidating symptom. Deep brain stimulation (DBS) allows for an improvement of PD motor features, but its effects on mood are difficult to predict. Here, we review the evidence regarding mood effects after DBS of either subthalamic nucleus (STN) or globus pallidus pars interna (GPi). Different influences of multiple factors contribute...

Université de Neuchâtel

Under-detection of endospore-forming Firmicutes in metagenomic data

Filippidou, Sevasti ; Junier, Thomas ; Wunderlin, Tina ; Lo, Chien-Chi ; Li, Po-E ; Chain, Patrick S ; Junier, Pilar

In: Computational and Structural Biotechnology Journal, 2015, vol. 13, p. 299-206

Microbial diversity studies based on metagenomic sequencing have greatly enhanced our knowledge of the microbial world. However, one caveat is the fact that not all microorganisms are equally well detected, questioning the universality of this approach. Firmicutes are known to be a dominant bacterial group. Several Firmicutes species are endospore formers and this property makes...

Université de Fribourg

Overproduction of H2S, generated by CBS, inhibits mitochondrial Complex IV and suppresses oxidative phosphorylation in Down syndrome

Panagaki, Theodora ; Randi, Elisa B. ; Augsburger, Fiona ; Szabo, Csaba

In: Proceedings of the National Academy of Sciences, 2019, p. 201911895

Down syndrome (DS) is associated with significant perturbances in mitochondrial function. Here we tested the hypothesis that the suppression of mitochondrial electron transport in DS cells is due to high expression of cystathionine-β-synthase (CBS) and subsequent overproduction of the gaseous transmitter hydrogen sulfide (H2S). Fibroblasts from DS individuals showed higher CBS expression...

Université de Neuchâtel

Ecosystem engineers’ contribution to soil structure formation in floodplains

Schomburg, Andreas ; Le Bayon, Claire (Dir.) ; Guenat, Claire (Codir.) ; Brunner, Philip (Codir.)

Thèse de doctorat : Université de Neuchâtel, 2019.

Soil structure formation constitutes an extremely important process in near-natural and restored floodplains. A stable soil structure protects riverbanks from erosion and contributes to the preservation of ecosystem services. However, developing a soil structure in alluvial soils is difficult for several reasons. Extensive alluvial dynamics cause periodic waterlogging and continuously rejuvenate...

Università della Svizzera italiana

Shp-2 is critical for ERK and metabolic engagement downstream of IL-15 receptor in NK cells

Niogret, Charlène ; Miah, S. M. Shahjahan ; Rota, Giorgia ; Fonta, Nicolas P. ; Wang, Haiping ; Held, Werner ; Birchmeier, Walter ; Sexl, Veronica ; Yang, Wentian ; Vivier, Eric ; Ho, Ping-Chih ; Brossay, Laurent ; Guarda, Greta

In: Nature communications, 2019, vol. 10, p. 1444

The phosphatase Shp-2 was implicated in NK cell development and functions due to its interaction with NK inhibitory receptors, but its exact role in NK cells is still unclear. Here we show, using mice conditionally deficient for Shp-2 in the NK lineage, that NK cell development and responsiveness are largely unaffected. Instead, we find that Shp-2 serves mainly to enforce NK cell responses to...

Università della Svizzera italiana

Sumoylation regulates the stability and nuclease activity of Saccharomyces cerevisiae Dna2

Ranjha, Lepakshi ; Levikova, Maryna ; Altmannova, Veronika ; Krejci, Lumir ; Cejka, Petr

In: Communications Biology, 2019, vol. 2, p. 174

Dna2 is an essential nuclease-helicase that acts in several distinct DNA metabolic pathways including DNA replication and recombination. To balance these functions and prevent unscheduled DNA degradation, Dna2 activities must be regulated. Here we show that Saccharomyces cerevisiae Dna2 function is controlled by sumoylation. We map the sumoylation sites to the N-terminal regulatory domain of...

Università della Svizzera italiana

Oxidation state dependent conformational changes of HMGB1 regulate the formation of the CXCL12/HMGB1 heterocomplex

Fassi, Enrico M.A. ; Sgrignani, Jacopo ; D'Agostino, Gianluca ; Cecchinato, Valentina ; Garofalo, Maura ; Grazioso, Giovanni ; Uguccioni, Mariagrazia ; Cavalli, Andrea

In: Computational and structural biotechnology journal, 2019, vol. 17, p. 886-894

High-mobility Group Box 1 (HMGB1) is an abundant protein present in all mammalian cells and involved in several processes. During inflammation or tissue damage, HMGB1 is released in the extracellular space and, depending on its redox state, can form a heterocomplex with CXCL12. The heterocomplex acts exclusively via the chemokine receptor CXCR4 enhancing leukocyte recruitment. Here, we used...