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Université de Lausanne

Tectonic and metamorphic evolution of the Central Himalayan Domain in Southeast Zanskar (Kashmir, India)

Dèzes, Pierre ; Steck, Albrecht (Dir.)

Thèse de doctorat : Université de Lausanne : 1999.

The southeastern part of Zanskar is located at the transition between two major Himalayan domains of contrasting metamorphic grade, the High Himalayan Crystalline Sequence (HHCS) and the Tethyan Himalaya (TH). The transition between the TH and the HHCS is marked by a very rapid, although perfectly gradual, decrease in metamorphic grade, which coincides with a major tectonic structure, the Zanskar...

Université de Lausanne

BoBo mixing meseasurement at Belle using dilepton events tagged with a soft pion

Ronga, Frédéric ; Schneider, Olivier (Dir.)

Thèse de doctorat : Université de Lausanne : 2003.

The Belle experiment is located in the KEK research centre (Japan) and is primarily devoted to the study of CP violation in the B meson sector. Belle is placed on the KEKB collider, one of the two currently running “B-meson factories”, which produce Banti-B pairs. KEKB has created more than 150 million pairs in total, a world record for this kind of colliders. This large sample allows very...

Université de Lausanne

Development of a hepatocyte hollow fiber bioreactor for the study of contrast agents by magnetic resonance imaging

Planchamp Messeiller, Corinne ; Testa, Bernard (Dir.)

Thèse de doctorat : Université de Lausanne : 2002.

Thanks to the continuous progress made in recent years, medical imaging has become an important tool in the diagnosis of various pathologies. In particular, magnetic resonance imaging (MRI) permits to obtain images with a remarkably high resolution without the use of ionizing radiation and is consequently widely applied for a broad range of conditions in all parts of the body. Contrast agents are...

Université de Lausanne

Comparaison objective de systèmes d'imagerie conventionnelle et numérique en mammographie

Pachoud, Marc ; Kühn, Lukas (Dir.)

Thèse de doctorat : Université de Lausanne : 2004.

The goal of this work was to develop a method to objectively compare the performance of a digital and a screen-film mammography system in terms of image quality and patient dose. We propose a method that takes into account the dynamic range of the image detector and the detection of high contrast (for microcalcifications) and low contrast (for masses or tumoral nodules) structures. The method...

Université de Lausanne

The Hydrophobic interaction: modeling hydrophobic interactions and aggregation of non-polar particles in aqueous solutions

Mölbert, Susanne ; De Los Rios, Paolo (Dir.)

Thèse de doctorat : Université de Lausanne : 2003.

Despite the importance of water in our daily lives, some of its properties remain unexplained. Indeed, the interactions of water with organic particles are investigated in research groups all over the world, but controversy still surrounds many aspects of their description. In my work I have tried to understand these interactions on a molecular level using both analytical and numerical methods....

Université de Lausanne

The use of positional scanning synthetic combinatorial libraries (PS-SCL) to study T Lympohcyte specificity and degeneracy

Meraldi, Verena ; Cerottini, Jean-Charles (Dir.)

Thèse de doctorat : Université de Lausanne : 2002.

CD8+ cytolytic T lymphocytes (CTL) are the main effector cells of the adaptive immune system against infection and tumors. The recent identification of moleculariy defined human tumor Ags recognized by autologous CTL has opened new opportunities for the development of Ag-specific cancer vaccines. Despite extensive work, however, the number of CTL-defined tumor Ags that are suitable targets for...

Université de Lausanne

Modules d'endo-permutation

Mazza, Nadia ; Thévenaz, Jacques (Dir.)

Thèse de doctorat : Université de Lausanne : 2003.

In modular representation theory, endo-permutation modules occupy an important position. Indeed, the role that these modules play, in the analysis of the structure of some particular simple modules for finite p-nilpotent groups, induced E. Dade, in 1978, to give them their current name. A few years later, L. Puig proved that the source of any simple module for any finite psolvable group is an...

Université de Lausanne

Etude de la toxicité hépatique de la cocaïne associée à de l'alcool : Effets de l'éthanol sur le métabolisme de la cocaïne dan les hépatocytes de rat en suspension et dans un modèle enzymatique humain

Berthoin, Karine ; Barret, Luc (Dir.) ; Mangin, Patrice (Codir.)

Thèse de doctorat : Université de Lausanne : 2000.

The main purpose of our work was to study the ability of the liver, as the first organ to metabolise xenobiotic substances, to degrade cocaine in the presence of ethanol. In order to do this, we used two experimental models, namely a cellular model (rat liver cells in suspension) and an a-cellular model (model reconstructed in vitro from purified human liver enzymes). The purpose of the first...

Université de Lausanne

Altruism, spite and choosy females

Lehmann, Laurent ; Perrin, Nicolas (Dir.)

Thèse de doctorat : Université de Lausanne : 2003.

Natural selection favours the genes which are able to introduce replicates of themselves in the next generation with higher certainty than do rival genes (Hamilton 1963). The fitness of an individual, it’s ability to produce future parents, depends on it’s own behaviour as well as on the behaviour of other individuals in the population. For instance, the intensity of competition an individual...