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Université de Fribourg

Estimating glacier-bed overdeepenings as possible sites of future lakes in the de-glaciating Mont Blanc massif (Western European Alps)

Magnin, F. ; Haeberli, W. ; Linsbauer, Andreas ; Deline, P. ; Ravanel, L.

In: Geomorphology, 2020, vol. 350, p. 106913

De-glaciating high mountain areas result in new landscapes of bedrock and debris where permafrost can degrade, persist or even newly form in cases, and of new lakes in glacier bed overdeepenings (GBOs) becoming ice-free. These landscapes with new lakes in close neighborhood to over-steepened and perennially frozen slopes are prone to chain reaction processes (e.g. rock-ice avalanches into...

Université de Fribourg

Birds have peramorphic skulls, too: anatomical network analyses reveal oppositional heterochronies in avian skull evolution

Plateau, Olivia ; Foth, Christian

In: Communications Biology, 2020, vol. 3, no. 1, p. 195

In contrast to the vast majority of reptiles, the skulls of adult crown birds are characterized by a high degree of integration due to bone fusion, e.g., an ontogenetic event generating a net reduction in the number of bones. To understand this process in an evolutionary context, we investigate postnatal ontogenetic changes in the skulls of crown bird and non-avian theropods using anatomical...

Université de Fribourg

Anchitheriinae (Perissodactyla, Equidae) from the early middle Miocene locality Gračanica (Bugojno Basin, Bosnia-Herzegovina)

Becker, Damien ; Tissier, Jérémy ; Vasilyan, Davit ; Göhlich, Ursula B.

In: Palaeobiodiversity and Palaeoenvironments, 2020, p. -

The early middle Miocene (European Land Mammal Zone MN5-earliest MN6) locality Gračanica (Bugojno Basin, Bosnia-Herzegovina) has yielded numerous well-preserved dental remains of two Anchitheriinae species: Anchitherium hippoides and Anchitherium ezquerrae. This anchithere assemblage is typical of the Orleanian European Land Mammal Age and is recorded for the first time in Southeastern...

Université de Fribourg

Role of 3-mercaptopyruvate sulfurtransferase in the regulation of proliferation, migration, and bioenergetics in murine colon cancer cells

Augsburger, Fiona ; Randi, Elisa B. ; Jendly, Mathieu ; Ascencao, Kelly ; Nahzli Dilek ; Szabo, Csaba

In: Biomolecules, 2020, vol. 10, no. 3, p. 447

3-mercaptopyruvate sulfurtransferase (3-MST) has emerged as one of the significant sources of biologically active sulfur species in various mammalian cells. The current study was designed to investigate the functional role of 3- MST’s catalytic activity in the murine colon cancer cell line CT26. The novel pharmacological 3-MST inhibitor HMPSNE was used to assess cancer cell proliferation,...

Université de Fribourg

Li0.5Ni0.5Ti1.5Fe0.5(PO4)3/C electrode material for lithium ion batteries exhibiting faster kinetics and enhanced stability

Srout, Mohammed ; Kwon, Nam Hee ; Ben Youcef, Hicham ; Semlal, Nawal ; Fromm, Katharina M. ; Saadoune, Ismael

In: ACS Applied Materials & Interfaces, 2020, vol. 12, no. 16, p. 18496–18503

Natrium super ionic conductor (NASICON) materials providing attractive properties such as high ionic conductivity and good structural stability are considered as very promising materials for use as electrodes for lithium- and sodium-ion batteries. Herein, a new high-performance electrode material, Li0.5Ni0.5Ti1.5Fe0.5(PO4)3/C, was synthesized via the sol–gel method and was...

Université de Fribourg

Improvement of the electrochemical performance by partial chemical substitution into the lithium site of titanium phosphate-based electrode materials for lithium-ion batteries: LiNi0.25Ti1.5 Fe0.5(PO4)3

Srout, Mohammed ; Kazzi, Mario El ; Youcef, Hicham Ben ; M.Fromm, Katharina ; Saadoune, Ismael

In: Journal of Power Sources, 2020, vol. 461, p. 228114

Partial lithium substitution with nickel (0.25 of Ni2+ ion) in the previously reported Li1.5Fe0.5Ti1.5(PO4)3/C (LFTP@C) was performed to improve its structural and electrochemical properties. The new LiNi0.25Fe0.5Ti1.5(PO4)3/C (LNFTP@C) material was then tested as electrode for lithium ion batteries. In the voltage window 1.85V–3.0 V vs. Li+/Li, attractive electrochemical performances were...

Université de Fribourg

Use of EpiAlveolar lung model to predict fibrotic potential of multiwalled carbon nanotubes

Barosova, Hana ; Maione, Anna G. ; Septiadi, Dedy ; Sharma, Monita ; Haeni, Laetitia ; Balog, Sandor ; O’Connell, Olivia ; Jackson, George R. ; Brown, David ; Clippinger, Amy J. ; Hayden, Patrick ; Petri-Fink, Alke ; Stone, Vicki ; Rothen-Rutishauser, Barbara

In: ACS Nano, 2020, vol. 14, no. 4, p. 3941–3956

Expansion in production and commercial use of nanomaterials increases the potential human exposure during the lifecycle of these materials (production, use, and disposal). Inhalation is a primary route of exposure to nanomaterials; therefore it is critical to assess their potential respiratory hazard. Herein, we developed a three-dimensional alveolar model (EpiAlveolar) consisting of human...

Université de Fribourg

Lipid nanoparticles biocompatibility and cellular uptake in a 3D human lung model

Magalhães, Joana ; Pinheiro, Marina ; Drasler, Barbara ; Septiadi, Dedy ; Petri-Fink, Alke ; Santos, Susana G ; Rothen-Rutishauser, Barbara ; Reis, Salette

In: Nanomedicine, 2020, vol. 15, no. 3, p. 259–271

Aim: Design nanostructured lipid carriers (NLC) to facilitate drug delivery to tuberculosis-infected areas, exploiting macrophage mannose receptors and assess their uptake in a 3D human lung model. Materials & methods: NLCs and mannosylated-NLCs were synthetized and characterized. Their uptake and biocompatibility were tested in a 3D human lung model. Results: The formulations have...

Université de Fribourg

COFs meet graphene nanoribbons

Fritz, Patrick Walter ; Coskun, Ali

In: Chem, 2020, vol. 6, no. 5, p. 1046–1048

2D covalent organic frameworks (COFs) have received considerable attention because of their crystallinity, permanent porosity, and tunability, yet they exhibit low in-plane conductivity. In this issue of Chem, Fischer and co-workers report an approach for growing 2D COF thin films featuring high in-plane conductivity for potential use in organic electronics.

Université de Fribourg

Effects of anti-PD-1 immunotherapy on tumor regression: insights from a patient-derived xenograft model

Martín-Ruiz, Asunción ; Fiuza-Luces, Carmen ; Martínez-Martínez, Esther ; Arias, Clemente F. ; Gutiérrez, Lourdes ; Ramírez, Manuel ; Martín-Acosta, Paloma ; Coronado, Maria José ; Lucia, Alejandro ; Provencio, Mariano

In: Scientific Reports, 2020, vol. 10, no. 1, p. 7078

Immunotherapies, such as checkpoint blockade of programmed cell death protein-1 (PD-1), have resulted in unprecedented improvements in survival for patients with lung cancer. Nonetheless, not all patients benefit equally and many issues remain unresolved, including the mechanisms of action and the possible effector function of immune cells from non-lymphoid lineages. The purpose of this...