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Université de Fribourg

Terahertz-driven phonon upconversion in SrTiO 3

Kozina, M. ; Fechner, M. ; Marsik, Premysl ; Driel, T. van ; Glownia, J. M. ; Bernhard, Christian ; Radovic, M. ; Zhu, D. ; Bonetti, S. ; Staub, U. ; Hoffmann, M. C.

In: Nature Physics, 2019, vol. 15, no. 4, p. 387–392

Direct manipulation of the atomic lattice using intense long-wavelength laser pulses has become a viable approach to create new states of matter in complex materials. Conventionally, a high-frequency vibrational mode is driven resonantly by a mid- infrared laser pulse and the lattice structure is modified through indirect coupling of this infrared-active phonon to other, lower-frequency...

Université de Fribourg

Benchmarking smartphone fluorescence-based microscopy with DNA origami nanobeads: reducing the gap toward single-molecule sensitivity

Vietz, Carolin ; Schütte, Max L. ; Wei, Qingshan ; Richter, Lars ; Lalkens, Birka ; Aydogan Ozcan ; Tinnefeld, Philip ; Acuna, Guillermo P.

In: ACS Omega, 2019, vol. 4, no. 1, p. 637–642

Smartphone-based fluorescence microscopy has been rapidly developing over the last few years, enabling point-of-need detection of cells, bacteria, viruses, and biomarkers. These mobile microscopy devices are cost-effective, field-portable, and easy to use, and benefit from economies of scale. Recent developments in smartphone camera technology have improved their performance, getting closer...

Université de Fribourg

Regulation of global CD8+ T-cell positioning by the actomyosin cytoskeleton

Stein, Jens V. ; Ruef, Nora

In: Immunological Reviews, 2019, vol. 289, no. 1, p. 232–249

CD8+ T cells have evolved as one of the most motile mammalian cell types, designed to continuously scan peptide–major histocompatibility complexes class I on the surfaces of other cells. Chemoattractants and adhesion molecules direct CD8+ T‐cell homing to and migration within secondary lymphoid organs, where these cells colocalize with antigen‐presenting dendritic cells in confined...

Université de Fribourg

Type I interferon/IRF7 axis instigates chemotherapy-induced immunological dormancy in breast cancer

Lan, Qiang ; Peyvandi, Sanam ; Duffey, Nathalie ; Huang, Yu-Ting ; Barras, David ; Held, Werner ; Richard, François ; Delorenzi, Mauro ; Sotiriou, Christos ; Desmedt, Christine ; Lorusso, Girieca ; Rüegg, Curzio

In: Oncogene, 2019, vol. 38, no. 15, p. 2814–2829

Neoadjuvant and adjuvant chemotherapies provide survival benefits to breast cancer patients, in particular in estrogen receptor negative (ER−) cancers, by reducing rates of recurrences. It is assumed that the benefits of (neo)adjuvant chemotherapy are due to the killing of disseminated, residual cancer cells, however, there is no formal evidence for it. Here, we provide experimental...

Université de Fribourg

Not just fundamental research: education, equal opportunities, knowledge and technology transfer, and communication at the nccr bio-inspired materials

Capper, Scott ; Haskal, Eliav ; Kilbinger, Andreas ; Montero de Espinosa, Lucas ; Rothen-Rutishauser, Barbara ; Rüegg, Curzio ; Weder, Christoph

In: CHIMIA International Journal for Chemistry, 2019, vol. 73, no. 1, p. 86–89

Besides conducting excellent fundamental research in domains of strategic importance, the National Centers of Competence in Research (NCCRs) also aim to become centers of reference for education, equal opportunities, and knowledge and technology transfer. These activities are supported by a communication strategy focused on specific target groups. This article describes some of the main...

Université de Fribourg

Prevalence of fosfomycin resistance among ESBL-producing Escherichia coli isolates in the community, Switzerland

Mueller, Linda ; Cimen, Cansu ; Poirel, Laurent  ; Descombes, Marie-Christine  ; Nordmann, Patrice 

In: European Journal of Clinical Microbiology & Infectious Diseases, 2019, vol. 38, no. 5, p. 945–949

Our aim was to evaluate the prevalence of fosfomycin-resistant strains among ESBL- producing Escherichia coli isolates recovered from community patients in Switzerland. A total of 1225 ESBL-producing E. coli isolates were collected between 2012 and 2013 from a private and community laboratory. Fosfomycin resistance was assessed by using the novel rapid fosfomycin/E. coli NP test and agar...

Université de Fribourg

Measuring physical load in soccer: strengths and limitations of 3 different methods

Fischer-Sonderegger, Karin ; Taube, Wolfgang ; Rumo, Martin ; Tschopp, Markus

In: International Journal of Sports Physiology and Performance, 2019, vol. 14, no. 5, p. 627–634

To investigate the strengths and limitations of different indicators to measure physical load. Furthermore, indicators were evaluated for discrimination between performance levels and playing positions. Methods: Ninety positional match files from 70 elite players and 91 match files from 69 subelite players were collected during 14 official under-18 matches using a local position measurement...