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Université de Fribourg

Characterization of FosL1, a plasmid-encoded fosfomycin resistance protein identified in Escherichia coli

Kieffer, Nicolas ; Poirel, Laurent ; Descombes, Marie-Christine ; Nordmann, Patrice

In: Antimicrobial Agents and Chemotherapy, 2020, vol. 64, no. 4, p. -

Fosfomycin is gaining renewed interest for treating urinary tract infections. Monitoring fosfomycin resistance is therefore important in order to detect the emergence of novel resistance mechanisms. Here, we used the Rapid Fosfomycin NP test to screen a collection of extended-spectrum-β-lactamase- producing Escherichia coli isolates from Switzerland and found a fosfomycin- resistant isolate...

Université de Fribourg

γδ T cells kill Plasmodium falciparum in a granzyme- and granulysin-dependent mechanism during the late blood stage

Hernández-Castañeda, Maria Andrea ; Happ, Katharina ; Cattalani, Filippo ; Wallimann, Alexandra ; Blanchard, Marianne ; Fellay, Isabelle ; Scolari, Brigitte ; Lannes, Nils ; Mbagwu, Smart Ikechukwu ; Fellay, Benoît ; Filgueira, Luis ; Mantel, Pierre-Yves ; Walch, Michael

In: The Journal of Immunology, 2020, vol. 204, no. 7, p. 1798–1809

Plasmodium spp., the causative agent of malaria, have a complex life cycle. The exponential growth of the parasites during the blood stage is responsible for almost all malaria-associated morbidity and mortality. Therefore, tight immune control of the intraerythrocytic replication of the parasite is essential to prevent clinical malaria. Despite evidence that the particular lymphocyte subset ...

Université de Fribourg

Training‐, muscle‐ and task‐specific up‐ and downregulation of cortical inhibitory processes

Taube, Wolfgang ; Gollhofer, Albert ; Lauber, Benedikt

In: European Journal of Neuroscience, 2020, vol. 51, no. 6, p. 1428–1440

Motor cortical contribution was shown to be important for balance control and for ballistic types of movements. However, little is known about the role of cortical inhibitory mechanisms and even less about long(er)‐term adaptations of these inhibitory processes. Therefore, the aim of the present study was to investigate the role of intracortical inhibition before and after four weeks of ...

Université de Fribourg

Countermovement jump training is more effective than drop jump training in enhancing jump height in non-professional female volleyball players

Ruffieux, Jan ; Wälchli, Michael ; Kim, Kyung-Min ; Taube, Wolfgang

In: Frontiers in Physiology, 2020, vol. 11, p. -

The aim of the present study was to compare the effects of countermovement jump (CMJ) and drop jump (DJ) training on the volleyball-specific jumping ability of non-professional female volleyball players. For that purpose, 26 female volleyball players (15–32 years) were assigned to either a CMJ (20.4 ± 3.1 years, 171.0 ± 3.0 cm) or a DJ training group (22.0 ± 4.4 years, 168.2 ± 5.0 cm), ...

Université de Fribourg

Allodynography: reliability of a new procedure for objective clinical examination of static mechanical allodynia

Packham, Tara L ; Spicher, Claude J ; Mac, Dermid, Joy C ; Buckley, Norman D

In: Pain Medicine, 2020, vol. 21, no. 1, p. 101–108

There is a need for reliable and valid clinical assessment tools for quantifying allodynia in neuropathic pain. Allodynography has been proposed as a useful standardized procedure for clinical assessment of mechanical allodynia. This study (www.clinicaltrials.gov NCT02070367) undertook preliminary investigation of the measurement properties of allodynography, a new standardized clinical ...

Université de Fribourg

Postnatal development of the entorhinal cortex: a stereological study in macaque monkeys

Piguet, Olivia ; Chareyron, Loïc J. ; Banta Lavenex, Pamela ; Amaral, David G. ; Lavenex, Pierre

In: Journal of Comparative Neurology, 2020, p. cne.24897

The entorhinal cortex is the main gateway for interactions between the neocortex and the hippocampus. Distinct regions, layers, and cells of the hippocampal formation exhibit different profiles of structural and molecular maturation during postnatal development. Here, we provide estimates of neuron number, neuronal soma size, and volume of the different layers and subdivisions of the monkey...

Université de Fribourg

Effects of theta burst stimulation over the dorsolateral prefrontal cortex on language switching – A behavioral and ERP study

Pestalozzi, Maria I. ; Annoni, Jean-Marie ; Müri, René M. ; Jost, Lea B.

In: Brain and Language, 2020, vol. 205, p. 104775

This study investigated the role of the left dorsolateral prefrontal cortex (DLPFC) in language switching using theta burst stimulation (TBS) and electroencephalography in late bilinguals. After a sham-controlled baseline, participants received either excitatory or inhibitory TBS over the left DLPFC before conducting picture naming tasks in pure language blocks and a language switching...

Haute Ecole pédagogique Fribourg

Relation entre disciplines scolaires et "Éducations à" : proposition d’un cadre d’analyse = Relationship between school disciplines and "Educations à": proposal of an analysis framework

Lebrun, Johanne ; Roy, Patrick ; Bousadra, Fatima ; Franc, Serge

In: McGill Journal of Education/Revue des sciences de l’éducation de McGill, 2019, vol. 54, no. 2, p. 646-669

This text lays the conceptual foundations for a framework to analyse the relationships between school disciplines, particularly those in the natural sciences and the humanities, and "Éducations à" in order to conduct comparative analyses of curricula in the Frenchspeaking world. The text first discusses the main characteristics of "Éducations à" and then circumscribes the areas of tension...

Université de Fribourg

Vulnérabilité et enfance en danger : Quel rapport ? Quels apports ?

Soulet, Marc-Henry

In: Vulnérabilité, identification des risques et protection de l’enfance. Nouveaux éclairages croisés / Lardeux L. (éd.), 2014, p. 128-139