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Université de Fribourg

In vivo nuclear translocation of mineralocorticoid and glucocorticoid receptors in rat kidney: differential effect of corticosteroids along the distal tubule

Ackermann, Daniel ; Gresko, Nikolay ; Carrel, Monique ; Loffing-Cueni, Dominique ; Habermehl, Daniel ; Gomez-Sanchez, Celso ; Rossier, Bernard C. ; Loffing, Johannes

In: American Journal of Physiology - Renal Physiology, 2011, vol. 299, no. 6, p. F1473-F1485

Aldosterone and corticosterone bind to mineralocorticoid (MR) and glucocorticoid receptors (GR), which, upon ligand binding, are thought to translocate to the cell nucleus to act as transcription factors. Mineralocorticoid selectivity is achieved by the 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) that inactivates 11β-hydroxy glucocorticoids. High expression levels of 11β-HSD2...

Université de Fribourg

Der Weg zur Suffizienz : Eine qualitative Studie über suffizient orientierte Lebensführungen in der Schweiz

Ackermann, Ronja ; Grunder, Carima ; Reisinger, Tina

In: sozialpolitik.ch, 2016, vol. 2, no. 2, p. Forum: 2.2

Der vorliegende Beitrag stützt sich auf die Ergebnisse einer qualitativen Forschungs-arbeit über suffizient orientierte Lebensführungen in der Schweiz. Diese wurde im Rahmen eines zweijährigen Forschungspraktikums des Studienbereichs Soziologie, Sozialarbeit und Sozialpolitik der Universität Fribourg als Bachelorarbeit geschrie-ben. Die Studie befasst sich mit suffizient orientierten...

Consortium of Swiss Academic Libraries

Differential Effects of Non-REM and REM Sleep on Memory Consolidation?

Ackermann, Sandra ; Rasch, Björn

In: Current Neurology and Neuroscience Reports, 2014, vol. 14, no. 2, p. 1-10

Université de Fribourg

Understanding amyloid aggregation by statistical analysis of atomic force microscopy images

Adamcik, Jozef ; Jung, Jin-Mi ; Flakowski, Jérôme ; Rios, Paolo De Los ; Dietler, Giovanni ; Mezzenga, Raffaele

In: Nature Nanotechnology, 2010, vol. 5, p. 423 - 428

The aggregation of proteins is central to many aspects of daily life, including food processing, blood coagulation, eye cataract formation disease and prion-related neurodegenerative infections. However, the physical mechanisms responsible for amyloidosis—the irreversible fibril formation of various proteins that is linked to disorders such as Alzheimer's, Creutzfeldt–Jakob and Huntington's...

Consortium of Swiss Academic Libraries

Fiscal Federalism for Emerging Economies: Lessons from Switzerland?

Adamovich, Ivan Baron ; Hosp, Gerald

In: Publius: The Journal of Federalism, 2003, vol. 33, no. 1, p. 1-21

Université de Fribourg

Robust changes and sources of uncertainty in the projected hydrological regimes of Swiss catchments

Addor, Nans ; Rössler, Ole ; Köplin, Nina ; Huss, Matthias ; Weingartner, Rolf ; Seibert, Jan

In: Water Resources Research, 2014, p. -

Projections of discharge are key for future water resources management. These projections are subject to uncertainties, which are difficult to handle in the decision process on adaptation strategies. Uncertainties arise from different sources such as the emission scenarios, the climate models and their post-processing, the hydrological models and natural variability. Here we present a detailed...

Université de Fribourg

Convexity of complements of tropical varieties, and approximations of currents

Adiprasito, Karim ; Babaee, Farhad

In: Mathematische Annalen, 2019, vol. 373, no. 1, p. 237–251

The goal of this note is to affirm a local version of conjecture of Nisse–Sottile [19] on higher convexity of complements of tropical varieties, while providing a family of counter-examples for the global Nisse–Sottle conjecture in any codimension and dimension higher than one. Moreover, it is shown that, surprisingly, this family also provides a family of counter-examples for the...

Université de Fribourg

Increased impulsive behavior and risk proneness following lentivirus-mediated dopamine transporter over-expression in rats' nucleus accumbens

Adriani, W. ; Boyer, Frederic ; Gioiosa, L. ; Macrì, S. ; Dreyer, Jean-Luc ; Laviola, G.

In: Neuroscience, 2009, vol. 159, no. 1, p. 47-58

Multiple theories have been proposed for sensation seeking and vulnerability to impulse-control disorders [Zuckerman M, Kuhlman DM (2000) Personality and risk-taking: Common biosocial factors. J Pers 68:999–1029], and many of these rely on a dopamine system deficit. Available animal models reproduce only some behavioral symptoms and seem devoid of construct validity. We used lentivirus tools...

Université de Fribourg

Social withdrawal and gambling-like profile after lentiviral manipulation of DAT expression in the rat accumbens

Adriani, Walter ; Boyer, Frederic ; Leo, Damiana ; Canese, Rossella ; Podo, Franca ; Perrone-Capano, Carla ; Dreyer, Jean-Luc ; Laviola, Giovanni

In: The International Journal of Neuropsychopharmacology, 2010, p. -

Dysfunction of brain dopamine transporter (DAT) has been associated with sensation seeking and impulse-control disorders. We recently generated a new animal model by stereotaxical inoculation of lentiviral vectors, which allowed localized intra-accumbal delivery of modulators for DAT gene: GFP (green fluorescent protein) control, silencers (Sil), a regulatable enhancer (DAT+), or both (DAT+Sil)....

Université de Fribourg

Drosophila suzukii: the genetic footprint of a recent, world-wide invasion

Adrion, Jeffrey R. ; Kousathanas, Athanasios ; Pascual, Marta ; Burrack, Hannah J. ; Haddad, Nick M. ; Bergland, Alan O. ; Machado, Heather ; Sackton, Timothy B. ; Schlenke, Todd A. ; Watada, Masayoshi ; Wegmann, Daniel ; Singh, Nadia D.

In: Molecular Biology and Evolution, 2014, p. msu246

Native to Asia, the soft-skinned fruit pest Drosophila suzukii has recently invaded the United States and Europe. The eastern United States represents the most recent expansion of their range, and presents an opportunity to test alternative models of colonization history. Here we investigate the genetic population structure of this invasive fruit fly, with a focus on the eastern United States. We...