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Université de Fribourg

A systematic review on the possible relationship between bilingualism, cognitive decline, and the onset of dementia

Noort, Maurits Van den ; Vermeire, Katrien ; Bosch, Peggy ; Staudte, Heike ; Krajenbrink, Trudy ; Jaswetz, Lars ; Struys, Esli ; Yeo, Sujung ; Barisch, Pia ; Perriard, Benoît ; Lee, Sook-Hyun ; Lim, Sabina

In: Behavioral Sciences, 2019, vol. 9, no. 7, p. 81

A systematic review was conducted to investigate whether bilingualism has a protective effect against cognitive decline in aging and can protect against dementia. We searched the Medline, ScienceDirect, Scopus, and ERIC databases with a cut-off date of 31 March 2019, thereby following the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) protocol....

Université de Fribourg

Biological sex influences antibody responses to routine vaccinations in the first year of life

Zimmermann, Petra ; Perrett, Kirsten P. ; Ritz,  Nicole ; Flanagan, Katie L. ; Robins-Browne, Roy ; Klis, Fiona R. M. van der ; Curtis, Nigel ; the MIS BAIR group

In: Acta Paediatrica, 2019, p. -

Aim We investigated the effect of early-life factors, namely sex, delivery mode, feeding method and antibiotic exposure, on antibody responses to routine vaccinations administered during the first year of life. Methods One and seven months after the primary course of routine vaccines and 1 month after routine vaccines at 12 months of age, antibodies against 26 vaccine antigens were measured...

Université de Fribourg

Looking back: twenty years of reforming undergraduate medical training and curriculum frameworks in Switzerland = Blick in den Rückspiegel: zwanzig Jahre Reformen der humanmedizinischen Studiengänge und der curricularen Rahmenbedingungen in der Schweiz

Bonvin, Raphael ; Nendaz, Mathieu ; Frey, Peter ; Schnabel, Kai P. ; Huwendiek, Sören ; Schirlo, Christian

In: GMS Journal for Medical Education, 2019, vol. 36, no. 5, p. Doc64

Introduction: To date, hardly any reports exist that outline the reforms in medical studies in Switzerland from the first partial reforms in the 1970s until today.Methods: This article outlines the recent history of medical curricula, their reforms in the early 1970s and, based on these, the key reasons for the major curricular reforms of the 2000s from the perspective of the authors.Results: The...

Université de Fribourg

Effects of statins to reduce all-cause mortality in heart failure patients: findings from the epical2 cohort study

Al‑Gobari, Muaamar ; Agrinier, Nelly ; Soudant, Marc ; Burnand, Bernard ; Thilly, Nathalie

In: American Journal of Cardiovascular Drugs, 2019, vol. 19, no. 5, p. 497–508

Introduction: The addition of statins to standard care in heart failure (HF) patients remains controversial in clinical practice. Large-scale clinical trials failed to show mortality benefits, but uncertainty persists in real-world settings.Objective: We evaluated whether the prescription of statins at hospital discharge is associated with a reduction in all-cause mortality at up to 1 year of...

Université de Fribourg

Medicine in the fourth dimension

R.Cederroth, Christopher ; Albrecht, Urs ; Bass, Joseph ; Brown, Steven A. ; Dyhrfjeld-Johnsen, Jonas ; Gachon, Frederic ; Green, Carla B. ; Hastings, Michael H. ; Helfrich-Förster, Charlotte ; B.Hogenesch, John ; Lévi, Francis ; Loudon, Andrew ; B.Lundkvist, Gabriella ; H.Meijer, Johanna ; Rosbash, Michael ; S.Takahashi, Joseph ; Young, Michael ; Canlon, Barbara

In: Cell Metabolism, 2019, vol. 30, no. 2, p. 238–250

The importance of circadian biology has rarely been considered in pre-clinical studies, and even more when translating to the bedside. Circadian biology is becoming a critical factor for improving drug efficacy and diminishing drug toxicity. Indeed, there is emerging evidence showing that some drugs are more effective at nighttime than daytime, whereas for others it is the opposite. This...

Université de Fribourg

Reducing the Domination Number of Graphs via Edge Contractions

Galby, Esther ; Lima, Paloma T. ; Ries, Bernard

In: 44th International Symposium on Mathematical Foundations of Computer Science (MFCS 2019) - LIPICS Vol. 138, 2019, p. 41:1-41:13

In this paper, we study the following problem: given a connected graph G, can we reduce the domination number of G by at least one using k edge contractions, for some fixed integer k >= 0? We show that for k <= 2, the problem is coNP-hard. We further prove that for k=1, the problem is W[1]-hard parameterized by the size of a minimum dominating set plus the mim-width of the input graph, and that...

Public access from Sep 15, 2021
Université de Fribourg

Maximum eccentric connectivity index for graphs with given diameter

Hauweele, Pierre ; Hertz, Alain ; Mélot, Hadrien ; Ries, Bernard ; Devillez, Gauvain

In: Discrete Applied Mathematics, 2019, vol. 268, p. 102-111

The eccentricity of a vertex v in a graph G is the maximum distance between v and any other vertex of G. The diameter of a graph G is the maximum eccentricity of a vertex in G. The eccentric connectivity index of a connected graph is the sum over all vertices of the product between eccentricity and degree. Given two integers n and D with D ≤ n−1, we characterize those graphs which have...

Université de Fribourg

Reducing the Domination Number of Graphs via Edge Contractions

Galby, Esther ; Lima, Paloma T. ; Ries, Bernard

In: 44th International Symposium on Mathematical Foundations of Computer Science (MFCS 2019), 2014, no. 41, p. 1-13

In this paper, we study the following problem: given a connected graph G, can we reduce the domination number of G by at least one using k edge contractions, for some fixed integer k >=0? We show that for k <=2, the problem is coNP-hard. We further prove that for k = 1, the problem is W[1]-hard parameterized by the size of a minimum dominating set plus the mim-width of the input graph, and...

Università della Svizzera italiana

Adjuvants and the vaccine response to the DS-Cav1-stabilized fusion glycoprotein of respiratory syncytial virus

Sastry, Mallika ; Zhang, Baoshan ; Chen, Man ; Joyce, M. Gordon ; Kong, Wing-Pui ; Chuang, Gwo-Yu ; Ko, Kiyoon ; Kumar, Azad ; Silacci, Chiara ; Thom, Michelle ; Salazar, Andres M. ; Corti, Davide ; Lanzavecchia, Antonio ; Taylor, Geraldine ; Mascola, John R. ; Graham, Barney S. ; Kwong, Peter D.

In: Plos one, 2017, vol. 12, no. 10, p. e0186854

Appropriate adjuvant selection may be essential to optimize the potency and to tailor the immune response of subunit vaccines. To induce protective responses against respiratory syncytial virus (RSV)—a highly prevalent childhood pathogen without a licensed vaccine—we previously engineered a pre-fusion-stabilized trimeric RSV F (pre-F) “DS-Cav1” immunogen, which induced high titer...

Università della Svizzera italiana

Phenotype and specificity of T cells in primary human cytomegalovirus infection during pregnancy : IL-7Rpos long-term memory phenotype is associated with protection from vertical transmission

Mele, Federico ; Fornara, Chiara ; Jarrossay, David ; Furione, Milena ; Arossa, Alessia ; Spinillo, Arsenio ; Lanzavecchia, Antonio ; Gerna, Giuseppe ; Sallusto, Federica ; Lilleri, Daniele

In: Plos one, 2017, vol. 12, no. 11, p. e0187731

Congenital human cytomegalovirus (HCMV) infection is the major cause of birth defects and a precise definition of the HCMV-specific T-cell response in primary infection may help define reliable correlates of immune protection during pregnancy. In this study, a high throughput method was used to define the frequency of CD4+ and CD8+ T cells specific for four HCMV proteins in the naïve...