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Università della Svizzera italiana

Microclimates and the city : towards an architectural theory of thermal diversity

Roesler, Sascha ; Kobi, Madlen

In: The urban microclimate as artifact : towards an architectural theory of thermal diversity, 2018, p. 12-24

The term “microclimate” was coined by German and British meteorologists and geographers in the first half of the 20th century. Rudolf Geiger and Albert Kratzer realized that the climate in the air layer “two meters above the ground” differs considerably between rural and urban sites. W.G.V. Balchin and Norman Pye proved that the urban climate within one city, Bath, was not homogenous,...

Università della Svizzera italiana

Systems analysis of MVA-C induced immune response reveals its significance as a vaccine candidate against HIV/AIDS of clade C

Gómez, Carmen Elena ; Perdiguero, Beatriz ; Jiménez, Victoria ; Filali-Mouhim, Abdelali ; Ghneim, Khader ; Haddad, Elias K. ; Quakkerlaar, Esther D. ; Delaloye, Julie ; Harari, Alexandre ; Roger, Thierry ; Dunhen, Thomas ; Sékaly, Rafick P. ; Melief, Cornelis J. M. ; Calandra, Thierry ; Sallusto, Federica ; Lanzavecchia, Antonio ; Wagner, Ralf ; Pantaleo, Giuseppe ; Esteban, Mariano

In: Plos one, 2012, vol. 7, no. 4, p. e35485

Based on the partial efficacy of the HIV/AIDS Thai trial (RV144) with a canarypox vector prime and protein boost, attenuated poxvirus recombinants expressing HIV-1 antigens are increasingly sought as vaccine candidates against HIV/AIDS. Here we describe using systems analysis the biological and immunological characteristics of the attenuated vaccinia virus Ankara strain expressing the HIV-1...

Università della Svizzera italiana

Enhancement of chemokine function as an immunomodulatory strategy employed by human herpesviruses

Viejo-Borbolla, Abel ; Martinez-Martín, Nadia ; Nel, Hendrik J. ; Rueda, Patricia ; Martín, Rocío ; Blanco, Soledad ; Arenzana-Seisdedos, Fernando ; Thelen, Marcus ; Fallon, Padraic G. ; Alcamí, Antonio

In: Plos pathogens, 2012, vol. 8, no. 2, p. e1002497

Herpes simplex virus (HSV) types 1 and 2 are highly prevalent human neurotropic pathogens that cause a variety of diseases, including lethal encephalitis. The relationship between HSV and the host immune system is one of the main determinants of the infection outcome. Chemokines play relevant roles in antiviral response and immunopathology, but the modulation of chemokine function by HSV is...

Università della Svizzera italiana

Characterization of variable regions of the Gp120 protein from HIV-1 subtype C virus variants obtained from individuals at different disease stages in Sub-Saharan Africa

Cenci, A. ; Tavoschi, L. ; D'Avenio, G. ; Narino, P. ; Becattini, S. ; Bernasconi, D. ; Chiappi, M. ; La Torre, L. ; Sukati, H. ; Vardas, E. ; Lo Presti, A. ; Cella, E. ; Ciccozzi, M. ; Picconi, O. ; Monini, P. ; Ensoli, B. ; Buttò, S.

In: Journal of AIDS & clinical research, 2012, vol. S8:006, p. 1-10

Background: The development of a vaccine against HIV/AIDS capable of preventing virus infection has been hampered by the HIV envelope (Env) heterogeneity that makes it difficult to induce neutralizing antibodies against Env proteins from different HIV clades. Several studies have indicated that gp120 Env protein sequence tends to change considerably during the course of HIV disease which...

Università della Svizzera italiana

MiR-146a in immunity and disease

Rusca, Nicole ; Monticelli, Silvia

In: Molecular biology international, 2011, vol. 2011, p. 1-7

MicroRNAs (miRNAs) are regulatory molecules able to influence all aspects of the biology of a cell. They have been associated with diseases such as cancer, viral infections, and autoimmune diseases, and in recent years, they also emerged as important regulators of immune responses. MiR-146a in particular is rapidly gaining importance as a modulator of differentiation and function of cells of...

Università della Svizzera italiana

MiR-221 influences effector functions and actin cytoskeleton in mast cells

Mayoral, Ramon J. ; Deho, Lorenzo ; Rusca, Nicole ; Bartonicek, Nenad ; Saini, Harpreet Kaur ; Enright, Anton J. ; Monticelli, Silvia

In: Plos one, 2011, vol. 6, no. 10, p. e26133

Mast cells have essential effector and immunoregulatory functions in IgE-associated allergic disorders and certain innate and adaptive immune responses, but the role of miRNAs in regulating mast cell functions is almost completely unexplored. To examine the role of the activation-induced miRNA miR-221 in mouse mast cells, we developed robust lentiviral systems for miRNA overexpression and...

Haute école de santé Genève

Diabète de type I et polyols : quels informations et conseils transmettre aux patients ? : travail de Bachelor

Carrupt, Damien ; Gay, Gaëlle ; Kehl Dubois, Corinne (Dir.)

Mémoire de bachelor : Haute école de santé Genève, 2017.

Introduction : L’objectif de la prise en charge du diabète de type 1 (DT1) est de maintenir la glycémie au plus proche des normes physiologiques afin d’éviter et/ou de retarder les complications à court et à long terme. Sur le plan alimentaire, la méthode actuellement préconisée par l’American Diabetes Association (ADA) est le comptage des glucides. Il permet d’ajuster au mieux le...

Haute école de santé Genève

Lésés médullaires : les motivations perçues lors de la pratique d'une activité physique de loisir. Une revue qualitative : travail de Bachelor

Aeberhard, Aurélie ; Herrmann, Natacha ; Cuvelier, Virginie (Dir.)

Mémoire de bachelor : Haute école de santé Genève, 2017.

Introduction : L’activité physique (AP) permet d’améliorer la qualité de vie car elle agit sur la santé physique et psychique ainsi que sur la sphère sociale des individus. Malheureusement, les lésés médullaires (LM) diminuent leur taux d’AP après leur lésion, ce qui accélère l’apparition de maladies liées à la sédentarité. A cela s’ajoutent les complications dues au...

Université de Fribourg

Nationalsozialistische und protofaschistische Sympathien an der Universität Freiburg i. Ü. : Die Ausweisung von Josef Spieler und die Neubesetzung des Lehrstuhls für Heilpädagogik durch Eduard Montalta

Künzler, Daniel ; Tschanz, Christoph

In: sozialpolitik.ch, 2019, vol. 1, no. 1, p. Forum: 1,1

Der aus Deutschland stammende Josef Spieler hatte an der Universität Freiburg in der Schweiz von 1933 bis 1945 eine Professur in „Psychologie, Pädagogik und Heilpädagogik“ inne. Diese wurde ihm 1945 entzogen und er musste wegen nationalsozialistischen Sympa-thien 1947 die Schweiz verlassen. Die Forschung hat diese Vorkommnisse teilweise aufgear-beitet und sich, wenngleich zögerlich, auch...