In: Cell host & microbe, 2019, vol. 26, no. 5, p. p. 623-637.e8
Potent and broadly neutralizing antibodies (bnAbs) are the hallmark of HIV-1 protection by vaccination. The membrane-proximal external region (MPER) of the HIV-1 gp41 fusion protein is targeted by the most broadly reactive HIV-1 neutralizing antibodies. Here, we examine the structural and molecular mechansims of neutralization by anti-MPER bnAb, LN01, which was isolated from lymph-node-derived...
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In: Plos one, 2012, vol. 7, no. 4, p. e35485
Based on the partial efficacy of the HIV/AIDS Thai trial (RV144) with a canarypox vector prime and protein boost, attenuated poxvirus recombinants expressing HIV-1 antigens are increasingly sought as vaccine candidates against HIV/AIDS. Here we describe using systems analysis the biological and immunological characteristics of the attenuated vaccinia virus Ankara strain expressing the HIV-1...
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In: Plos one, 2011, vol. 6, no. 2, p. e16819
Attenuated poxviruses are safe and capable of expressing foreign antigens. Poxviruses are applied in veterinary vaccination and explored as candidate vaccines for humans. However, poxviruses express multiple genes encoding proteins that interfere with components of the innate and adaptive immune response. This manuscript describes two strategies aimed to improve the immunogenicity of the...
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In: Neurological Sciences, 2013, vol. 34, no. 4, p. 539-543
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In: Journal of Infectious Diseases, 1998, vol. 177, no. 6, p. 1497-1501
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In: Journal of Infectious Diseases, 1997, vol. 176, no. 4, p. 924-932
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In: The Journal of Infectious Diseases, 2000, vol. 182, no. 1, p. 311-315
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In: Clinical Infectious Diseases, 2015, vol. 60, no. 3, p. 432-437
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In: Brain, 2008, vol. 131, no. 7, p. 1712-1721
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In: Journal of Infectious Diseases, 2012, vol. 205, p. S147-S158
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