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Consortium of Swiss Academic Libraries

"Jnking” atherosclerosis

Sumara, G. ; Belwal, M. ; Ricci, R.

In: Cellular and Molecular Life Sciences CMLS, 2005, vol. 62, no. 21, p. 2487-2494

Consortium of Swiss Academic Libraries

Cell cycle regulation by the B-Myb transcription factor

Joaquin, M. ; Watson, R.

In: Cellular and Molecular Life Sciences CMLS, 2003, vol. 60, no. 11, p. 2389-2401

Université de Neuchâtel

The novel chloroplast outer membrane kinase KOC1 is a required component of the plastid protein import machinery

Zufferey-Arias, Mónica Alexandra ; Kessler, Felix (Dir.)

Thèse de doctorat : Université de Neuchâtel, 2017.

The chloroplast constitutes the site of photosynthesis and is an essential organelle in plant cells. An endosymbiotic event was at the origin of the chloroplast, an ancestral eukaryotic cell engulfing a photosynthetic cyanobacterium. During evolution, the majority of ancestral chloroplast genes were lost or transferred to the nucleus. The protein products of the successfully transferred genes are...

Université de Neuchâtel

The Novel Chloroplast Outer Membrane Kinase KOC1 Is a Required Component of the Plastid Protein Import Machinery

Zufferey, Mónica ; Montandon, Cyrille ; Douet, Véronique ; Demarsy, Emilie ; Agne, Birgit ; Baginsky, Sacha ; Kessler, Felix

In: Journal of biological chemistry, 2017, vol. 292, no. 17, p. 6952-6964

The biogenesis and maintenance of cell organelles such as mitochondria and chloroplasts require the import of many proteins from the cytosol, a process that is controlled by phosphorylation. In the case of chloroplasts, the import of hundreds of different proteins depends on translocons at the outer and inner chloroplast membrane (TOC and TIC, respectively) complexes. The essential protein TOC159...

Université de Fribourg

Phospho-proteomic analyses of B-Raf protein complexes reveal new regulatory principles

Eisenhardt, Anja E. ; Sprenger, Adrian ; Röring, Michael ; Herr, Ricarda ; Weinberg, Florian ; Köhler, Martin ; Braun, Sandra ; Orth, Joachim ; Diedrich, Britta ; Lanner, Ulrike ; Tscherwinski, Natalja ; Schuster, Simon ; Dumaz, Nicolas ; Schmidt, Enrico ; Baumeister, Ralf ; Schlosser, Andreas ; Dengjel, Jörn ; Brummer, Tilman

In: Oncotarget, 2016, vol. 7, no. 18, p. 26628–26652

B-Raf represents a critical physiological regulator of the Ras/RAF/MEK/ERK-pathway and a pharmacological target of growing clinical relevance, in particular in oncology. To understand how B-Raf itself is regulated, we combined mass spectrometry with genetic approaches to map its interactome in MCF-10A cells as well as in B-Raf deficient murine embryonic fibroblasts (MEFs) and B-Raf/Raf-1...

Université de Fribourg

Epigenetic and posttranslational modifications in light signal transduction and the circadian clock in Neurospora crassa

Proietto, Marco ; Bianchi, Michele Maria ; Ballario, Paola ; Brenna, Andrea

In: International Journal of Molecular Sciences, 2015, vol. 16, no. 7, p. 15347–15383

Blue light, a key abiotic signal, regulates a wide variety of physiological processes in many organisms. One of these phenomena is the circadian rhythm presents in organisms sensitive to the phase-setting effects of blue light and under control of the daily alternation of light and dark. Circadian clocks consist of autoregulatory alternating negative and positive feedback loops intimately...