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Université de Fribourg

Drosophila germ-line modulation of insulin signaling and lifespan

Flatt, Thomas ; Min, Kyung-Jin ; D'Alterio, Cecilia ; Villa-Cuesta, Eugenia ; Cumbers, John ; Lehmann, Ruth ; Jones, D. Leanne ; Tatar, Marc

In: Proceedings of the National Academy of Sciences of the United States of America, 2008, vol. 105, no. 17, p. 6368–6373

Ablation of germ-line precursor cells in Caenorhabditis elegans extends lifespan by activating DAF-16, a forkhead transcription factor (FOXO) repressed by insulin/insulin-like growth factor (IGF) signaling (IIS). Signals from the gonad might thus regulate whole-organism aging by modulating IIS. To date, the details of this systemic regulation of aging by the reproductive system are not...

Consortium of Swiss Academic Libraries

Reactive oxygen species and nitric oxide in viral diseases

Peterhans, Ernst

In: Biological Trace Element Research, 1997, vol. 56, no. 1, p. 107-116