Università della Svizzera italiana

Higher-order connections between stereotyped subsets : implications for improved patient classification in CLL

Agathangelidis, Andreas ; Chatzidimitriou, Anastasia ; Gemenetzi, Katerina ; Giudicelli, Veronique ; Karypidou, Maria ; Plevova, Karla ; Davis, Zadie ; Yan, Xiao-Jie ; Jeromin, Sabine ; Schneider, Christof ; Bredo-Pedersen, Lone ; Tschumper, Renee C. ; Sutton, Lesley-Ann ; Baliakas, Panagiotis ; Scarfò, Lydia ; van Gastel, Ellen J. ; Armand, Marine ; Tausch, Eugen ; Biderman, Bella ; Baer, Constance ; Bagnara, Davide ; Navarro, Alba ; Langlois de Septenville, Anne ; Guido, Valentina ; Mitterbauer-Hohendanner, Gerlinde ; Dimovski, Aleksandar ; Brieghel, Christian ; Lawless, Sarah ; Meggendorfer, Manja ; Braazdilova, Kamila ; Ritgen, Matthias ; Facco, Monica ; Tresoldi, Cristina ; Visentin, Andrea ; Patriarca, Andrea ; Catherwood, Mark ; Bonello, Lisa ; Sudarikov, Andrey ; Vanura, Katrina ; Roumelioti, Maria ; Skuhrova-Francova, Hana ; Moysiadis, Theodoros ; Veronese, Silvio ; Giannopoulos, Krzysztof ; Mansouri, Larry ; Karan-Djurasevic, Teodora ; Sandaltzopoulos, Raphael ; Bödör, Csaba ; Fais, Franco ; Kater, Arnon ; Panovska, Irina ; Rossi, Davide ; Alshemmari, Salem ; Panagiotidis, Panagiotis ; Costeas, Paul ; Espinet Solà, Blanca ; Antic, Darko ; Foroni, Letizia ; Montillo, Marco ; Trentin, Livio ; Stavroyianni, Niki ; Gaidano, Gianluca ; Francia di Celle, Paola ; Niemann, Carsten ; Campo, Elias ; Anagnostopoulos, Achilles ; Pott, Christiane ; Fischer, Kirsten ; Hallek, Michael ; Oscier, David ; Stilgenbauer, Stephan ; Haferlach, Claudia ; Jelinek, Diane ; Chiorazzi, Nicholas ; Pospisilova, Sarka ; Lefranc, Marie-Paule ; Kossida, Sofia ; Langerak, Anton W. ; Belessi, Chrysoula ; Davi, Frederic ; Rosenquist, Richard ; Ghia, Paolo ; Stamatopoulos, Kostas

In: Blood, 2020, vol. 137, no. 10, p. 1365–1376

Chronic lymphocytic leukemia (CLL) is characterized by the existence of subsets of patients with (quasi)identical, stereotyped B cell receptor immunoglobulins (BcR IG). Patients in certain major stereotyped subsets often display remarkably consistent clinicobiological profiles, suggesting that the study of BcR IG stereotypy in CLL has important implications for understanding disease...