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Università della Svizzera italiana

Proteostasis : bad news and good news from the endoplasmic reticulum

Noack, Julia ; Brambilla Pisoni, Giorgia ; Molinari, Maurizio

In: Swiss medical weekly, 2014, vol. 144, p. w14001

The endoplasmic reticulum (ER) is an intracellular compartment dedicated to the synthesis and maturation of secretory and membrane proteins, totalling about 30% of the total eukaryotic cells proteome. The capacity to produce correctly folded polypeptides and to transport them to their correct intra- or extracellular destinations relies on proteostasis networks that regulate and balance the...

Università della Svizzera italiana

Chemical stresses fail to mimic the unfolded protein response resulting from luminal load with unfolded polypeptides

Bergmann, Timothy J. ; Fregno, Ilaria ; Fumagalli, Fiorenza ; Rinaldi, Andrea ; Bertoni, Francesco ; Boersema, Paul J. ; Picotti, Paola ; Molinari, Maurizio

In: Journal of biological chemistry, 2018, vol. 293, no. 15, p. 5600-5612

The stress sensors ATF6, IRE1, and PERK monitor deviations from homeostatic conditions in the endoplasmic reticulum (ER), a protein biogenesis compartment of eukaryotic cells. Their activation elicits unfolded protein responses (UPR) to reestablish proteostasis. UPR have been extensively investigated in cells exposed to chemicals that activate ER stress sensors by perturbing calcium, N-glycans,...

Université de Neuchâtel

Identification et caractérisation de protéines antigéniques de 'Borrelia burgdorferi' sensu lato

Wyss, Jean-Christophe ; Peter, Oliver (Dir.) ; Betschart, Bruno (Codir.)

Thèse de doctorat : Université de Neuchâtel, 2012.

Borrelia afzelii, B. garinii, and B. burgdorferi are three of the five Borrelia species definitely recognized as responsible for Lyme borreliosis in Europe. This infectious disease is transmitted by ticks and is characterized by multistage skin, joint, neurological and cardiac manifestations. The aim of the present study is to reveal new species specific proteins of B....