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Université de Fribourg

Phage idiotype vaccination: first phase I/II clinical trial in patients with multiple myeloma

Roehnisch, Tim ; Then, Cornelia ; Nagel, Wolfgang ; Blumenthal, Christina ; Braciak, Todd ; Donzeau, Mariel ; Böhm, Thomas ; Flaig, Michael ; Bourquin, Carole ; Oduncu, Fuat S

In: Journal of Translational Medicine, 2014, vol. 12, no. 1, p. 119

Background: Multiple myeloma is characterized by clonal expansion of B cells producing monoclonal immunoglobulins or fragments thereof, which can be detected in the serum and/or urine and are ideal target antigens for patient-specific immunotherapies.Methods: Using phage particles as immunological carriers, we employed a novel chemically linked idiotype vaccine in a clinical phase I/II trial...