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Université de Neuchâtel

Lyme disease

Gern, Lise ; Falco, R.C

In: Scientific and Technical Review of the Office International des Epizooties, 2000, vol. 19, no. 1, p. 121-135

Lyme borreliosis, the most common vector-bome disease in the northern hemisphere, is caused by bacteria belonging to the Borrelia burgdorferi complex. The disease is multisystemic, affecting mainly the skin, nervous system, heart and joints. In Europe, the vector of the disease is the tick Ixodes ricinus, whereas in the United States of America, two primary tick vectors exist,...

Université de Neuchâtel

Protective immunization with plasmid DNA containing the outer surface lipoprotein A gene of Borrelia burgdorferi is independent of an eukaryotic promoter

Simon, Markus M ; Gern, Lise ; Hauser, Pierre ; Zhong, Weimin ; Nielsen, Peter J ; Kramer, Michael D ; Brenner, Christiane ; Wallich, Reinhard

In: European Journal of Immunology, 1996, vol. 26, no. 12, p. 2831-2840

Plasmid DNA encoding the outer surface lipoprotein A (OspA) of Borrelia burgdorferi under the control of either strong eukaryotic/viral or its own bacterial promoter was injected intramuscularly (m. tibialis anterior) or intradermally into BALB/c and AKR/N mice. OspA-specific antibodies and OspA-reactive T helper 1 cells (Th1) were induced only with those plasmids containing the...

Université de Neuchâtel

T helper cell priming of mice to Borrelia burgdorferi Osp A leads to induction of protective antibodies following experimental but not tickborne infection

Zhong, Weimin ; Gern, Lise ; Kramer, Michael ; Wallich, Reinhard ; Simon, Markus M

In: European Journal of Immunology, 1997, vol. 27, no. 11, p. 2942-2947

Antibodies to the outer surface lipoprotein A (Osp A) of Borrelia burgdorferi confer protection to SCID mice against subsequent tick-borne or experimental infection. However, Osp A-specific antibodies are hardly detectable in naturally infected humans, dogs, hamsters and mice. This is most probably due to limited expression of Osp A on spirochetes transmitted from the vector to the...

Université de Neuchâtel

Resolution of experimental and tick-borne Borrelia burgdorferi infection in mice by passive, but not active immunization using recombinant OspC

Zhong, Weimin ; Gern, Lise ; Stehle, Thomas ; Museteanu, Crisan ; Kramer, Michael ; Wallich, Reinhard ; Simon, Markus M

In: European Journal of Immunology, 1999, vol. 29, no. 3, p. 946-957

Vaccination with outer surface protein A (OspA) of Borrelia burgdorferi prevents subsequent infection and disease in both laboratory animals and humans with high efficacy. OspA-based immunity, however, does not affect established infection due to the loss of OspA expression in the vertebrate host. We show here that repeated passive transfer of mouse and/or rabbit immune sera to...

Université de Neuchâtel

Identification et caractérisation de protéines antigéniques de 'Borrelia burgdorferi' sensu lato

Wyss, Jean-Christophe ; Peter, Oliver (Dir.) ; Betschart, Bruno (Codir.)

Thèse de doctorat : Université de Neuchâtel, 2012.

Borrelia afzelii, B. garinii, and B. burgdorferi are three of the five Borrelia species definitely recognized as responsible for Lyme borreliosis in Europe. This infectious disease is transmitted by ticks and is characterized by multistage skin, joint, neurological and cardiac manifestations. The aim of the present study is to reveal new species specific proteins of B....

Université de Neuchâtel

Confirmation that Rickettsia helvetica sp. nov. Is a Distinct Species of the Spotted Fever Group of Rickettsiae

Beati, Lorenza ; Péter, Olivier ; Burgdorfer, Willy ; Aeschlimann, André ; Raoult, Didier

In: International Journal of Systematic and Evolutionary Microbiology, 1993, vol. 43, no. 3, p. 521-526

We propose the name Rickettsia helvetica sp. nov. for a rickettsial serotype of unknown pathogenicity isolated in 1979 in Switzerland from Ixodes ricinus ticks and designated the Swiss agent. The growth characteristics and the results of microimmunofluorescence serologic typing, sodium dodecyl sulfate-polyacrylamide gel electrophoresis, Western blotting (immunoblotting) with...

Université de Neuchâtel

Ixodes (Pholeoixodes) hexagonus, an efficient vector of Borrelia burgdorferi in the laboratory

Gern, Lise ; Toutoungi, L. N. ; Hu, Chang Min ; Aeschlimann, André

In: Medical and Veterinary Entomology, 1991, vol. 5, no. 4, p. 431-435

Borrelia burgdorferi Johnson et al. was first isolated from the midgut of Ixodes dammini Spielman et al. in the U.S.A. and from the midgut of Lricinus (L.) in Europe. I.ricinus was considered to be the only tick vector of this borrelia, in Europe, until I.hexagonus Leach, the hedgehog tick, was found to harbour spirochaetes. This paper reports an evaluation of...