Université de Fribourg

Social withdrawal and gambling-like profile after lentiviral manipulation of DAT expression in the rat accumbens

Adriani, Walter ; Boyer, Frederic ; Leo, Damiana ; Canese, Rossella ; Podo, Franca ; Perrone-Capano, Carla ; Dreyer, Jean-Luc ; Laviola, Giovanni

In: The International Journal of Neuropsychopharmacology, 2010, p. -

Dysfunction of brain dopamine transporter (DAT) has been associated with sensation seeking and impulse-control disorders. We recently generated a new animal model by stereotaxical inoculation of lentiviral vectors, which allowed localized intra-accumbal delivery of modulators for DAT gene: GFP (green fluorescent protein) control, silencers (Sil), a regulatable enhancer (DAT+), or both (DAT+Sil)....