Université de Neuchâtel

From anticancer complexes to photoswitchable assemblies : new approaches in the design and synthesis of arene ruthenium species

Cheminel, Thomas ; Therrien, Bruno (Dir.)

Thèse de doctorat : Université de Neuchâtel, 2016.

The aim of the present thesis was to explore new approaches in the design and synthesis of new arene ruthenium species. This class of organometallic compounds has been the subject of much attention in the recent years due to their interesting properties in various fields, such as medicinal chemistry or supramolecular chemistry. In order to achieve this goal, this work was divided into two...

Université de Neuchâtel

Insight into the rules dictating the formation of arene ruthenium metalla-assemblies

Garci, Amine ; Therrien, Bruno (Dir.)

Thèse de doctorat : Université de Neuchâtel, 2015.

The self-assembly process is a natural phenomenon with the ability to organize biological systems. Its development by chemists as a synthetic process allowed the formation of esthetical structures as well as highly complex supramolecular systems with remarkable biological functions. Since 1990, metal directed self-assembly strategy has largely contributed to the design and synthesis of discrete...

Université de Neuchâtel

Complexes arène-ruthénium multinucléaires fluctuants : véhicules pour le transport intracellulaire de molécules cytotoxiques et photosensibilisantes

Freudenreich, Julien ; Süss-Fink, Georg (Dir.) ; Therrien, Bruno (Codir.)

Thèse de doctorat : Université de Neuchâtel, 2012.

Depuis plusieurs années, la thérapie photo-dynamique est pratiquée au quotidien pour soigner certaines tumeurs, comme le mélanome. La méthode consiste à traiter le patient au moyen d’un composé photosensible, indifféremment absorbé par les cellules normales et cancéreuses, ces dernières le retenant toutefois plus longtemps. Après plusieurs heures, le composé est activé par une...

Université de Neuchâtel

Synthesis and Anticancer Activity of Long-Chain Isonicotinic Ester Ligand-Containing Arene Ruthenium Complexes and Nanoparticles

Süss-Fink, Georg ; Khan, Farooq-Ahmad ; Juillerat-Jeanneret, Lucienne ; Dyson, Paul J. ; Renfrew, Anna K.

In: Journal of Cluster Science, 2010, vol. 21, no. 3, p. 313-324

Arene ruthenium complexes containing long-chain N-ligands L1 = NC5H4–4-COO–C6H4–4-O–(CH2)9–CH3 or L2 = NC5H4–4-COO–(CH2)10–O–C6H4–4-COO–C6H4–4-C6H4–4-CN...