Université de Neuchâtel

Anti-hemostatic Effects of a Serpin from the Saliva of the Tick Ixodes ricinus

Prevot, Pierre-Paul ; Adam, Benoit ; Zouaoui Boudjeltia, Karim ; Brossard, Michel ; Lins, Laurence ; Cauchie, Philippe ; Brasseur, Robert ; Vanhaeverbeek, Michel ; Vanhamme, Luc ; Godfroid, Edmond

In: Journal of Biological Chemistry, 2006, vol. 281, no. 36, p. 26361-26369

Serpins (serine protease inhibitors) are a large family of structurally related proteins found in a wide variety of organisms, including hematophagous arthropods. Protein analyses revealed that Iris, previously described as an immunomodulator secreted in the tick saliva, is related to the leukocyte elastase inhibitor and possesses serpin motifs, including the reactive center...