Université de Fribourg

Preventing implant-associated infections by silver coating

Kuehl, Richard ; Brunetto, Priscilla S. ; Woischnig, Anne-Kathrin ; Varisco, Massimo ; Rajacic, Zarko ; Vosbeck, Juerg ; Terracciano, Luigi ; Fromm, Katharina M. ; Khanna, Nina

In: Antimicrobial Agents and Chemotherapy, 2016, p. AAC.02934–15

Implant-associated infections (IAI) are a dreaded complication mainly caused by biofilm-forming staphylococci. Implant surfaces preventing microbial colonization would be desirable. We examined the preventive effect of a silver-coated titanium aluminium niobium (TiAlNb) alloy. The surface elicited a strong, inoculum-dependent activity against Staphylococcus (S.) epidermidis and S. aureus in an...

Université de Fribourg

Everolimus augments the effects of sorafenib in a syngeneic orthotopic model of hepatocellular carcinoma

Piguet, Anne-Christine ; Saar, Bettina ; Hlushchuk, Ruslan ; St-Pierre, Marie V ; McSheehy, Paul M ; Radojevic, Vesna ; Afthinos, Maresa ; Terracciano, Luigi ; Djonov, Valentin ; Dufour, Jean-Francois J.

In: Molecular Cancer Therapeutics, 2011, p. -

Sorafenib targets the Raf/mitogen activated protein kinase, VEGF and PDGF pathways and prolongs survival patients in advanced hepatocellular carcinoma (HCC). Everolimus inhibits the mammalian target of rapamycin, a kinase overactive in HCC. To investigate whether the antitumor effects of these agents are additive, we compared a combined and sequential treatment regimen of everolimus and sorafenib...