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Université de Fribourg

How dieting might make some fatter: modeling weight cycling toward obesity from a perspective of body composition autoregulation

Jacquet, Philippe ; Schutz, Yves ; Montani, Jean-Pierre ; Dulloo, Abdul

In: International Journal of Obesity, 2020, vol. 44, p. 1243-1253

The notion that dieting makes some people fatter has in the past decade gained considerable interest from both epidemiological predictions and biological plausibility. Several large-scale prospective studies have suggested that dieting to lose weight is associated with future weight gain and obesity, with such predictions being stronger and more consistent among dieters who are in the normal...

Université de Fribourg

Total energy expenditure assessed by doubly labeled water technique and estimates of physical activity in Mauritian children: analysis by gender and ethnicity

Ramuth, Harris ; Schutz, Yves ; Calonne, Julie ; Joonas, Noorjehan ; Dulloo, Abdul G.

In: European Journal of Clinical Nutrition, 2020, vol. 74, no. 3, p. 445–453

In the tropical island of Mauritius, the rise in obesity has accelerated in the past decades, and could be contributed by low physical activity and increased sedentary behavior. The study objectives were to generate the first dataset of total energy expenditure (TEE), to estimate physical activity in Mauritian children, and to explore differences due to gender and ethnicity.Subjects/methods:...

Université de Fribourg

Assessment of the dose–response relationship between meal protein content and postprandial thermogenesis: effect of sex and the oral contraceptive pill

Duhita, Maharani R. ; Schutz, Yves ; Montani, Jean-Pierre ; Dulloo, Abdul G. ; Miles-Chan, Jennifer L.

In: Nutrients, 2019, vol. 11, no. 7, p. 1599

Implementation of efficacious dietary interventions to regulate energy balance requires understanding of the determinants of individual response. To date, information regarding individual variability in response to elevated meal protein content is lacking. This study investigates whether sex and/or oral contraceptive pill (OCP) use play a role in the response to elevated meal protein in 21...

Université de Fribourg

European practical and patient-centred guidelines for adult obesity management in primary care

Durrer Schutz, D. ; Busetto, L. ; Dicker, D. ; Farpour-Lambert, N. ; Pryke, R. ; Toplak, H. ; Widmer, D. ; Yumuk, V. ; Schutz, Yves

In: Obesity Facts, 2019, vol. 12, no. 1, p. 40–66

The first contact for patients with obesity for any medical treatment or other issues is generally with General Practitioners (GPs). Therefore, given the complexity of the disease, continuing GPs’ education on obesity management is essential. This article aims to provide obesity management guidelines specifically tailored to GPs, favouring a practical patient-centred approach. The focus is...

Université de Fribourg

Comparison of conventional and individualized 1-MET values for expressing maximum aerobic metabolic rate and habitual activity related energy expenditure

Heydenreich, Juliane ; Schutz, Yves ; Melzer, Katarina ; Kayser, Bengt

In: Nutrients, 2019, vol. 11, no. 2, p. 458

The maximum aerobic metabolic rate can be expressed in multiple metabolically equivalent tasks (MET), i.e., METmax. The purpose was to quantify the error when the conventional (3.5 mL∙kg−1∙min−1) compared to an individualized 1-MET-value is used for calculating METmax and estimating activity energy expenditure (AEE) in endurance-trained athletes (END) and active healthy controls...

Université de Fribourg

The case of GWAS of obesity: does body weight control play by the rules?

Müller, Manfred J. ; Geisler, Corinna ; Blundell, John ; Dulloo, Abdul ; Schutz, Yves ; Krawczak, Michael ; Bosy-Westphal, Anja ; Enderle, Janna ; Heymsfield, Steven B.

In: International Journal of Obesity, 2018, vol. 42, no. 8, p. 1395–1405

As yet, genome-wide association studies (GWAS) have not added much to our understanding of the mechanisms of body weight control and of the etiology of obesity. This shortcoming is widely attributed to the complexity of the issues. The appeal of this explanation notwithstanding, we surmise that (i) an oversimplification of the phenotype (namely by the use of crude anthropometric traits) and...

Université de Fribourg

The contribution of Swiss scientists to the assessment of energy metabolism

Montani, Jean-Pierre ; Schutz, Yves ; Dulloo, Abdul G.

In: European Journal of Clinical Nutrition, 2018, vol. 72, no. 5, p. 665–679

Although Switzerland is considered a small country, it has its share in discoveries, inventions and developments for the assessment of energy metabolism. This includes seminal contributions to respiratory and metabolic physiology and to devices for measuring energy expenditure by direct and indirect calorimetry in vivo in humans and small animals (as well as in vitro in organs/tissues), for...

Université de Fribourg

Collateral fattening in body composition autoregulation: its determinants and significance for obesity predisposition

Dulloo, Abdul G. ; Miles-Chan, Jennifer L. ; Schutz, Yves

In: European Journal of Clinical Nutrition, 2018, vol. 72, no. 5, p. 657–664

Collateral fattening refers to the process whereby excess fat is deposited as a result of the body’s attempt to counter a deficit in lean mass through overeating. Its demonstration and significance to weight regulation and obesity can be traced to work on energy budget strategies in growing mammals and birds, and to men recovering from experimental starvation. The cardinal features of...