Université de Fribourg

Effects of the circadian rhythm gene period 1 (Per1) on psychosocial stress-Induced alcohol drinking

Dong, Li ; Bilbao, Ainhoa ; Laucht, Manfred ; Henriksson, Richard ; Yakovleva, Tatjana ; Ridinger, Monika ; Desrivieres, Sylvane ; Clarke, Toni-Kim ; Lourdusamy, Anbarasu ; Smolka, Michael N. ; Cichon, Sven ; Blomeyer, Dorothea ; Treutlein, Jens ; Perreau-Lenz, Stephanie ; Witt, Stephanie ; Leonardi-Essmann, Fernando ; Wodarz, Norbert ; Zill, Peter ; Soyka, Michael ; Albrecht, Urs ; Rietschel, Marcella ; Lathrop, Mark ; Bakalkin, Georgy ; Spanagel, Rainer ; Schumann, Gunter

In: American Journal of Psychiatry, 2011, vol. 168, no. 10, p. 1090-1098

Objective: Circadian and stress-response systems mediate environmental changes that affect alcohol drinking. Psychosocial stress is an environmental risk factor for alcohol abuse. Circadian rhythm gene period 1 (Per1) is targeted by stress hormones and is transcriptionally activated in corticotropin releasing factor-expressing cells. The authors hypothesized that Per1 is involved in integrating...

Université de Fribourg

Ethanol self-administration and reinstatement of ethanol-seeking behavior in Per1Brdm1 mutant mice

Zghoul, Tarek ; Abarca, Carolina ; Sanchis-Segura, Carles ; Albrecht, Urs ; Schumann, Gunter ; Spanagel, Rainer

In: Psychopharmacology, 2007, vol. 190, no. 1, p. 13-19

Rationale Alcohol consumption shows circadian rhythmicity, i.e., alcohol preference and intake change with circadian time. Circadian rhythmicity is controlled by a biological clock, which has been shown to govern behavioral, physiological, and hormonal processes in synchronization with internal as well as external cues. Molecular components of the clock include circadian clock genes such as...

Université de Fribourg

The clock gene Per2 influences the glutamatergic system and modulates alcohol consumption

Spanagel, Rainer ; Pendyala, Gurudutt ; Abarca, Carolina ; Zghoul, Tarek ; Sanchis-Segura, Carles ; Magnone, Maria Chiara ; Lascorz, Jesús ; Depner, Martin ; Holzberg, David ; Soyka, Michael ; Schreiber, Stefan ; Matsuda, Fumihiko ; Lathrop, Mark ; Schumann, Gunter ; Albrecht, Urs

In: Nature Medicine, 2004, vol. 11, p. 35-42

Period (Per) genes are involved in regulation of the circadian clock and are thought to modulate several brain functions. We demonstrate that Per2Brdm1 mutant mice, which have a deletion in the PAS domain of the Per2 protein, show alterations in the glutamatergic system. Lowered expression of the glutamate transporter Eaat1 is observed in these animals, leading to reduced uptake of glutamate by...