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Université de Fribourg

Restricted diffusion of calretinin in cerebellar granule cell dendrites implies Ca²⁺-dependent interactions via its EF-hand 5 domain

Arendt, Oliver ; Schwaller, Beat ; Brown, Edward B. ; Eilers, Jens ; Schmidt, Hartmut

In: The Journal of Physiology, 2013, p. –

Ca²⁺-binding proteins (CaBPs) are important regulators of neuronal Ca²⁺ signaling, acting either as buffers that shape Ca²⁺ transients and Ca²⁺ diffusion and/or as Ca²⁺ sensors. The diffusional mobility represents a crucial functional parameter of CaBPs, describing their range-of-action and possible interactions with binding partners. Calretinin (CR) is a CaBP widely expressed in...

Université de Fribourg

Parvalbumin is freely mobile in axons, somata and nuclei of cerebellar Purkinje neurones

Schmidt, Hartmut ; Arendt, Oliver ; Brown, Edward B. ; Schwaller, Beat ; Eilers, Jens

In: Journal of Neurochemistry, 2007, vol. 100, no. 3, p. 727–735

The Ca²⁺-binding protein (CaBP) parvalbumin (PV) is strongly expressed in cerebellar Purkinje neurones (PNs). It is considered a pure Ca²⁺ buffer, lacking any Ca²⁺ sensor function. Consistent with this notion, no PV ligand was found in dendrites of PNs. Recently, however, we observed for a related CaBP that ligand-targeting differs substantially between dendrites and axons. Thus, here we...