Université de Fribourg

Four individually identified paired dopamine neurons signal reward in larval Drosophila

Rohwedder, Astrid ; Wenz, Nana L. ; Stehle, Bernhard ; Huser, Annina ; Yamagata, Nobuhiro ; Zlatic, Marta ; Truman, James W. ; Tanimoto, Hiromu ; Saumweber, Timo ; Gerber, Bertram ; Thum, Andreas S.

In: Current Biology, 2016, vol. 26, no. 5, p. 661–669

Dopaminergic neurons serve multiple functions, including reinforcement processing during associative learning [1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 and 12]. It is thus warranted to understand which dopaminergic neurons mediate which function. We study larval Drosophila, in which only approximately 120 of a total of 10,000 neurons are dopaminergic, as judged by the expression of tyrosine...

Université de Fribourg

Neuropeptide F neurons modulate sugar reward during associative olfactory learning of Drosophila larvae

Rohwedder, Astrid ; Selcho, Mareike ; Chassot, Bérénice ; Thum, Andreas S.

In: Journal of Comparative Neurology, 2015, vol. 523, no. 18, p. 2637–2664

All organisms continuously have to adapt their behavior according to changes in the environment in order to survive. Experience-driven changes in behavior are usually mediated and maintained by modifications in signaling within defined brain circuits. Given the simplicity of the larval brain of Drosophila and its experimental accessibility on the genetic and behavioral level, we analyzed if...

Université de Fribourg

The serotonergic central nervous system of the drosophila larva: anatomy and behavioral function

Huser, Annina ; Rohwedder, Astrid ; Apostolopoulou, Anthi A. ; Widmann, Annekathrin ; Pfitzenmaier, Johanna E. R. ; Maiolo, Elena M. ; Selcho, Mareike ; Pauls, Dennis ; Essen, Alina von ; Gupta, Tripti ; Sprecher, Simon G. ; Birman, Serge ; Riemensperger, Thomas ; Stocker, Reinhard F. ; Thum, Andreas S.

In: PLoS ONE, 2012, vol. 7, no. 10, p. e47518

The Drosophila larva has turned into a particularly simple model system for studying the neuronal basis of innate behaviors and higher brain functions. Neuronal networks involved in olfaction, gustation, vision and learning and memory have been described during the last decade, often up to the single-cell level. Thus, most of these sensory networks are substantially defined, from the sensory...

Université de Fribourg

Nutritional value–Dependent and nutritional value–Independent effects on Drosophila melanogaster larval behavior

Rohwedder, Astrid ; Pfitzenmaier, Johanna E. ; Ramsperger, Noel ; Apostolopoulou, Anthi A. ; Widmann, Annekathrin ; Thum, Andreas S.

In: Chemical Senses, 2012, p. -

Gustatory stimuli allow an organism not only to orient in its environment toward energy-rich food sources to maintain nutrition but also to avoid unpleasant or even poisonous substrates. For both mammals and insects, sugars—perceived as “sweet”—potentially predict nutritional benefit. Interestingly, even Drosophila adult flies are attracted to most high-potency sweeteners preferred by...