Université de Neuchâtel

Under-detection of endospore-forming Firmicutes in metagenomic data

Filippidou, Sevasti ; Junier, Thomas ; Wunderlin, Tina ; Lo, Chien-Chi ; Li, Po-E ; Chain, Patrick S ; Junier, Pilar

In: Computational and Structural Biotechnology Journal, 2015, vol. 13, p. 299-206

Microbial diversity studies based on metagenomic sequencing have greatly enhanced our knowledge of the microbial world. However, one caveat is the fact that not all microorganisms are equally well detected, questioning the universality of this approach. Firmicutes are known to be a dominant bacterial group. Several Firmicutes species are endospore formers and this property makes...