Université de Fribourg

Impulsivity and home-cage activity are decreased by lentivirus-mediated silencing of serotonin transporter in the rat hippocampus

Zoratto, Francesca ; Tringle, Amanda L. ; Bellenchi, Giancarlo ; Speranza, Luisa ; Travaglini, Domenica ; diPorzio, Umberto ; Perrone-Capano, Carla ; Laviola, Giovanni ; Dreyer, Jean-Luc ; Adriani, Walter

In: Neuroscience Letters, 2013, vol. 548, p. 38–43

Brain serotonin (5-HT) systems modulate emotional, motivational and cognitive processes. Mutations in the serotonin transporter (SERT) gene have been associated with susceptibility towards the development of several psychiatric disorders, both in humans and animal models. Present approach exploited a bilateral intra-hippocampus stereotaxic inoculation of lentiviruses, for enduring in vivo...

Université de Fribourg

Social withdrawal and gambling-like profile after lentiviral manipulation of DAT expression in the rat accumbens

Adriani, Walter ; Boyer, Frederic ; Leo, Damiana ; Canese, Rossella ; Podo, Franca ; Perrone-Capano, Carla ; Dreyer, Jean-Luc ; Laviola, Giovanni

In: The International Journal of Neuropsychopharmacology, 2010, p. -

Dysfunction of brain dopamine transporter (DAT) has been associated with sensation seeking and impulse-control disorders. We recently generated a new animal model by stereotaxical inoculation of lentiviral vectors, which allowed localized intra-accumbal delivery of modulators for DAT gene: GFP (green fluorescent protein) control, silencers (Sil), a regulatable enhancer (DAT+), or both (DAT+Sil)....