Università della Svizzera italiana

Deciphering the complexity of human noncoding promoter-proximal transcriptome : different scales of transcriptional control : from a single gene to the whole epigenome

Mapelli, Sarah Natalia ; Krause, Rolf (Dir.) ; Catapano, Carlo V. (Codir.)

Thèse de doctorat : Università della Svizzera italiana, 2019 ; 2019INFO001.

Long noncoding RNAs (lncRNAs) have gained increasing interest in molecular studies, their active participation in important biological functions has emerged and their direct involvement in genomic reprogramming during development and diseases, including cancer, has been demonstrated. Several studies have shown their active contribution in transcriptional control and they are emerging as...

Public access from Jan 15, 2021
Università della Svizzera italiana

Modelling protein-protein interactions to elucidate molecular mechanisms behind neurodegenerative diseases

Grasso, Gianvito ; Krause, Rolf (Dir.) ; Danani, Andrea (Codir.)

Thèse de doctorat : Università della Svizzera italiana, 2018 ; 2018INFO017.

The worldwide significant increase in life expectancy has recently drawn the attention of the scientific community to neurodegenerative pathologies of the elderly population. These neurodegenerative disorders arise from the abnormal protein aggregation in the nervous tissue leading to intracellular inclusions or extracellular aggregates in specific brain areas. A feasible strategy to prevent...

Università della Svizzera italiana

Geometry–aware finite element framework for multi–physics simulations : an algorithmic and software-centric perspective

Zulian, Patrick ; Krause, Rolf (Dir.)

Thèse de doctorat : Università della Svizzera italiana, 2017 ; 2017INFO006.

In finite element simulations, the handling of geometrical objects and their discrete representation is a critical aspect in both serial and parallel scientific software environments. The development of codes targeting such envinronments is subject to great development effort and man-hours invested. In this thesis we approach these issues from three fronts. First, stable and efficient ...

Università della Svizzera italiana

Derivation, simulation and validation of poroelastic models in dental biomechanics

Favino, Marco ; Krause, Rolf (Dir.)

Thèse de doctorat : Università della Svizzera italiana, 2014 ; 2014INFO015.

Poroelasticity and mechanics of growth are playing an increasingly relevant role in biomechanics. This work is a self- contained and holistic presentation of the modeling and simulation of non-linear poroelasticity with and without growth inhomogeneities. Balance laws of poroelasticity are derived in Cartesian coordinates. These allow to write the governing equations in a form that is general...

Università della Svizzera italiana

The effects of roughness on the area of contact and on the elastostatic friction : FEM simulation of micro-scale rough contact and real world applications

Rigazzi, Alessandro Pietro ; Krause, Rolf (Dir.)

Thèse de doctorat : Università della Svizzera italiana, 2014 ; 2014INFO014.

Roughness is everywhere. Every object, every surface we touch or look at, is rough. Even when it looks smooth and flat, if analyzed at the proper length scale, it will reveal roughness. Thus, macro-scale, micro-scale, and even nano-scale roughness exist. What is even more fascinating, is that most of the rough structures, which can be observed at a given length scale, repeat themselves at...

Università della Svizzera italiana

Domain decomposition preconditioning for the Helmholtz equation : a coarse space based on local Dirichlet-to-Neumann maps

Conen, Lea ; Krause, Rolf (Dir.)

Thèse de doctorat : Università della Svizzera italiana, 2015 ; 2015INFO001.

In this thesis, we present a two-level domain decomposition method for the iterative solution of the heterogeneous Helmholtz equation. The Helmholtz equation governs wave propagation and scattering phenomena arising in a wide range of engineering applications. Its discretization with piecewise linear finite elements results in typically large, ill-conditioned, indefinite, and non- Hermitian...

Università della Svizzera italiana

Coupling different discretizations for fluid structure interaction in a monolithic approach

Steiner, Johannes ; Krause, Rolf (Dir.)

Thèse de doctorat : Università della Svizzera italiana, 2014 ; 2014INFO010.

In this thesis we present a monolithic coupling approach for the simulation of phenomena involving interacting fluid and structure using different discretizations for the subproblems. For many applications in fluid dynamics, the Finite Volume method is the first choice in simulation science. Likewise, for the simulation of structural mechanics the Finite Element method is one of the most, if...

Università della Svizzera italiana

Scalable space-time adaptive simulation tools for computational electrocardiology

Krause, Dorian ; Krause, Rolf (Dir.)

Thèse de doctorat : Università della Svizzera italiana, 2013 ; 2013INFO004.

This work is concerned with the development of computational tools for the solution of reaction-diffusion equations from the field of computational electrocardiology. We designed lightweight spatially and space-time adaptive schemes for large-scale parallel simulations. We propose two different adaptive schemes based on locally structured meshes, managed either via a conforming coarse...