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Université de Fribourg

Generation of SNP datasets for orangutan population genomics using improved reduced-representation sequencing and direct comparisons of SNP calling algorithms

Greminger, Maja P ; Stölting, Kai N ; Nater, Alexander ; Goossens, Benoit ; Arora, Natasha ; Bruggmann, Rémy ; Patrignani, Andrea ; Nussberger, Beatrice ; Sharma, Reeta ; Kraus, Robert H S ; Ambu, Laurentius N ; Singleton, Ian ; Chikhi, Lounes ; Schaik, Carel P van ; Krützen, Michael

In: BMC Genomics, 2014, vol. 15, no. 1, p. 16

Background: High-throughput sequencing has opened up exciting possibilities in population and conservation genetics by enabling the assessment of genetic variation at genome-wide scales. One approach to reduce genome complexity, i.e. investigating only parts of the genome, is reduced-representation library (RRL) sequencing. Like similar approaches, RRL sequencing reduces ascertainment bias due to...