Université de Fribourg

Solid-state structure and anti­microbial and cytotoxicity studies of a cucurbit[6]uril-like Cu6L4 constructed from 3,5-bis­[(1H-tetra­zol-5-yl)meth­yl]-4H-1,2,4-triazol-4-amine

Vasylevskyi, Serhii ; Holzheu, Anja ; Fromm, Katharina M.

In: Acta Crystallographica Section C: Structural Chemistry, 2018, vol. 74, no. 11, p. 1413–1419

3,5-Bis[(1H-tetra­zol-5-yl)meth­yl]-4H-1,2,4-triazol-4-amine (H2L) associates under deprotonation with CuSO4 in aqueous medium to form a new waisted barrel-shaped M6L4 cluster, namely hexa­aqua­tetra­kis­{μ4-3,5-bis­[(1H-tetra­zol-5-yl)meth­yl]-4H-1,2,4- triazol-4-amine}-μ4-sulfato-hexa­copper(II) sulfate hydrate, [Cu6(SO4) (C6H6N12)4(H2O)6]SO4·nH2O (n = ∼23) (1). Cluster 1...

Université de Fribourg

Synthesis of new polyether ether ketone derivatives with silver binding site and coordination compounds of their monomers with different silver salts

Girard, Jérôme ; Joset, Nathalie ; Crochet, Aurélien ; Tan, Milène ; Holzheu, Anja ; Brunetto, Priscilla S. ; Fromm, Katharina M.

In: Polymers, 2016, vol. 8, no. 6, p. 208

Polyether ether ketone (PEEK) is a well-known polymer used for implants and devices, especially spinal ones. To overcome the biomaterial related infection risks, 4-4′- difluorobenzophenone, the famous PEEK monomer, was modified in order to introduce binding sites for silver ions, which are well known for their antimicrobial activity. The complexation of these new monomers with different...