Université de Fribourg

Membrane stress is coupled to a rapid translational control of gene expression in chlorpromazine-treated cells

Filippi, Loic De ; Fournier, Margot ; Cameroni, Elisabetta ; Linder, Patrick ; De Virgilio, Claudio ; Foti, Michelangelo ; Deloche, Olivier

In: Current Genetics, 2007, vol. 52, no. 3-4, p. 171-185

Chlorpromazine (CPZ) is a small permeable cationic amphiphilic molecule that inserts into membrane bilayers and binds to anionic lipids such as poly-phosphoinositides (PIs). Since PIs play important roles in many cellular processes, including signaling and membrane trafficking pathways, it has been proposed that CPZ affects cellular growth functions by preventing the recruitment of proteins with...