Université de Fribourg

Understanding amyloid aggregation by statistical analysis of atomic force microscopy images

Adamcik, Jozef ; Jung, Jin-Mi ; Flakowski, Jérôme ; Rios, Paolo De Los ; Dietler, Giovanni ; Mezzenga, Raffaele

In: Nature Nanotechnology, 2010, vol. 5, p. 423 - 428

The aggregation of proteins is central to many aspects of daily life, including food processing, blood coagulation, eye cataract formation disease and prion-related neurodegenerative infections. However, the physical mechanisms responsible for amyloidosis—the irreversible fibril formation of various proteins that is linked to disorders such as Alzheimer's, Creutzfeldt–Jakob and Huntington's...