Université de Fribourg

Drosophila germ-line modulation of insulin signaling and lifespan

Flatt, Thomas ; Min, Kyung-Jin ; D'Alterio, Cecilia ; Villa-Cuesta, Eugenia ; Cumbers, John ; Lehmann, Ruth ; Jones, D. Leanne ; Tatar, Marc

In: Proceedings of the National Academy of Sciences of the United States of America, 2008, vol. 105, no. 17, p. 6368–6373

Ablation of germ-line precursor cells in Caenorhabditis elegans extends lifespan by activating DAF-16, a forkhead transcription factor (FOXO) repressed by insulin/insulin-like growth factor (IGF) signaling (IIS). Signals from the gonad might thus regulate whole-organism aging by modulating IIS. To date, the details of this systemic regulation of aging by the reproductive system are not...